Protein Download |
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Protein Name | Coagulation factor X | |||||
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#PDB ID | 85 | |||||
Organism | Homo sapiens | |||||
Uniprot ID/ACC | P00742 (FA10_HUMAN) | |||||
Protein Sequence | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK | |||||
Protein Class | HYDROLASE | |||||
Synonym(s) |
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Gene Symbol | F10 | |||||
Gene ID | 2159 | |||||
Pfam ID | PF00008, PF00594, PF00089 | |||||
Interpro ID | IPR017857, IPR001881, IPR000742, IPR000152, IPR018097, IPR035972, IPR000294, IPR012224, IPR009003, IPR043504, IPR001314, IPR001254, IPR018114, IPR033116 |
Bound Ligands |
HET ID | Ligand Type | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
XLD | Small Molecule | 1MQ6 | Ki : 0.01 nM, Ki : 0.29 nM | BindingDB | SHOW | |
XLD | Small Molecule | 1MQ6 | Ki : 0.007 nM | Binding MOAD | SHOW | |
RDR | Small Molecule | 1NFX | Ki : 3.0 nM | PDBBind | SHOW | |
RDR | Small Molecule | 1NFX | Ki : 3.0 nM | BindingDB | SHOW | |
RDR | Small Molecule | 1NFX | Ki : 3.0 nM | Binding MOAD | SHOW | |
RRR | Small Molecule | 1NFW | Ki : 1.1 nM | PDBBind | SHOW | |
RRR | Small Molecule | 1NFW | Ki : 1.1 nM | BindingDB | SHOW | |
RRR | Small Molecule | 1NFW | Ki : 1.1 nM | Binding MOAD | SHOW | |
PR2 | Small Molecule | 1F0S | Ki : 18.0 nM | PDBBind | SHOW | |
PR2 | Small Molecule | 1F0S | Ki : 18.0 nM | BindingDB | SHOW | |
PR2 | Small Molecule | 1F0S | Ki : 18.0 nM | Binding MOAD | SHOW | |
4PP | Small Molecule | 1XKA | IC50 : 270.0 nM, IC50 : 2.7 nM | BindingDB | SHOW | |
4PP | Small Molecule | 1XKA | Ki : 131.0 nM | Binding MOAD | SHOW | |
931 | Small Molecule | 2Y81 | Ki : 2.0 nM | PDBBind | SHOW | |
931 | Small Molecule | 2Y81 | Ki : 2.0 nM | BindingDB | SHOW | |
931 | Small Molecule | 2Y81 | Ki : 2.0 nM | Binding MOAD | SHOW | |
D14 | Small Molecule | 3IIT | IC50 : 9.5 nM, IC50 : 9.5 nM | Binding MOAD | SHOW | |
I1H | Small Molecule | 2BMG | Ki : 18.0 nM | PDBBind | SHOW | |
I1H | Small Molecule | 2BMG | Ki : 18.0 nM | BindingDB | SHOW | |
230 | Small Molecule | 2PHB | IC50 : 0.32 nM, IC50 : 0.57 nM | BindingDB | SHOW | |
230 | Small Molecule | 2PHB | IC50 : 0.32 nM | Binding MOAD | SHOW | |
RIV | Small Molecule | 2W26 | Ki : 0.66 nM, Ki : 0.4 nM, Ki : 1.6 nM, Ki : 8.5 nM, Ki : 0.7 nM, Ki : 2.2 nM, Ki : 4.59 nM, Ki : 400.0 nM, Ki : 1.4 nM, Ki : 14.0 nM, Ki : 700.0 nM | BindingDB | SHOW | |
RIV | Small Molecule | 2W26 | Ki : 0.4 nM | Binding MOAD | SHOW | |
LZG | Small Molecule | 2VWO | Ki : 31.0 nM | PDBBind | SHOW | |
LZG | Small Molecule | 2VWO | Ki : 31.0 nM | BindingDB | SHOW | |
CMB | Small Molecule | 1LPZ | Ki : 25.0 nM | PDBBind | SHOW | |
CMB | Small Molecule | 1LPZ | Ki : 25.0 nM | BindingDB | SHOW | |
CMB | Small Molecule | 1LPZ | Ki : 25.0 nM | Binding MOAD | SHOW | |
CMI | Small Molecule | 1LQD | Ki : 9.0 nM | PDBBind | SHOW | |
CMI | Small Molecule | 1LQD | Ki : 9.0 nM | BindingDB | SHOW | |
5QC | Small Molecule | 2FZZ | Ki : 0.03 nM | PDBBind | SHOW | |
5QC | Small Molecule | 2FZZ | Ki : 0.03 nM | BindingDB | SHOW | |
5QC | Small Molecule | 2FZZ | Ki : 0.03 nM | Binding MOAD | SHOW | |
IK8 | Small Molecule | 1Z6E | Ki : 0.19 nM, Ki : 1.6 nM | BindingDB | SHOW | |
IK8 | Small Molecule | 1Z6E | Ki : 0.19 nM | Binding MOAD | SHOW | |
M37 | Small Molecule | 3M37 | Ki : 0.91 nM, Ki : 2.9 nM | BindingDB | SHOW | |
XLC | Small Molecule | 1MQ5 | Ki : 0.76 nM, Ki : 1.0 nM | BindingDB | SHOW | |
XLC | Small Molecule | 1MQ5 | Ki : 1.0 nM | Binding MOAD | SHOW | |
FXA | Small Molecule | 3CEN | Ki : 5.5 nM | PDBBind | SHOW | |
FXA | Small Molecule | 3CEN | Ki : 5.5 nM | BindingDB | SHOW | |
FXA | Small Molecule | 3CEN | Ki : 5.5 nM | Binding MOAD | SHOW | |
L1C | Small Molecule | 2W3I | IC50 : 0.1 nM, IC50 : 1.32 nM | BindingDB | SHOW | |
L1C | Small Molecule | 2W3I | IC50 : 0.1 nM | Binding MOAD | SHOW | |
L1D | Small Molecule | 2W3K | IC50 : 0.08 nM | PDBBind | SHOW | |
L1D | Small Molecule | 2W3K | IC50 : 0.08 nM | BindingDB | SHOW | |
L1D | Small Molecule | 2W3K | IC50 : 0.08 nM | Binding MOAD | SHOW | |
D91 | Small Molecule | 1WU1 | IC50 : 18.0 nM | PDBBind | SHOW | |
D91 | Small Molecule | 1WU1 | IC50 : 18.0 nM | Binding MOAD | SHOW | |
C0Z | Small Molecule | 2Y7Z | Ki : 2.0 nM | PDBBind | SHOW | |
C0Z | Small Molecule | 2Y7Z | Ki : 2.0 nM | BindingDB | SHOW | |
C0Z | Small Molecule | 2Y7Z | Ki : 2.0 nM | Binding MOAD | SHOW | |
ME1 | Small Molecule | 2P93 | Ki : 1.5 nM | PDBBind | SHOW | |
ME1 | Small Molecule | 2P93 | Ki : 1.5 nM | BindingDB | SHOW | |
ME1 | Small Molecule | 2P93 | Ki : 1.5 nM | Binding MOAD | SHOW | |
D76 | Small Molecule | 1V3X | IC50 : 24.0 nM | PDBBind | SHOW | |
D76 | Small Molecule | 1V3X | IC50 : 24.0 nM | BindingDB | SHOW | |
D76 | Small Molecule | 1V3X | IC50 : 24.0 nM | Binding MOAD | SHOW | |
ME4 | Small Molecule | 2P94 | Ki : 0.67 nM | PDBBind | SHOW | |
ME4 | Small Molecule | 2P94 | Ki : 0.67 nM | BindingDB | SHOW | |
ME4 | Small Molecule | 2P94 | Ki : 0.67 nM | Binding MOAD | SHOW | |
ME5 | Small Molecule | 2P95 | Ki : 0.43 nM | PDBBind | SHOW | |
ME5 | Small Molecule | 2P95 | Ki : 0.43 nM | BindingDB | SHOW | |
ME5 | Small Molecule | 2P95 | Ki : 0.43 nM | Binding MOAD | SHOW | |
JNJ | Small Molecule | 2RA0 | Ki : 15.9 nM | PDBBind | SHOW | |
JNJ | Small Molecule | 2RA0 | Ki : 15.9 nM | BindingDB | SHOW | |
JNJ | Small Molecule | 2RA0 | Ki : 15.9 nM | Binding MOAD | SHOW | |
A7I | Small Molecule | 4A7I | Ki : 2.0 nM | PDBBind | SHOW | |
A7I | Small Molecule | 4A7I | Ki : 2.0 nM | Binding MOAD | SHOW | |
FFG | Small Molecule | 3FFG | Ki : 0.84 nM | PDBBind | SHOW | |
FFG | Small Molecule | 3FFG | Ki : 0.84 nM | BindingDB | SHOW | |
FFG | Small Molecule | 3FFG | Ki : 0.84 nM | Binding MOAD | SHOW | |
LGJ | Small Molecule | 3KQB | Ki : 0.5 nM | PDBBind | SHOW | |
LGJ | Small Molecule | 3KQB | Ki : 0.5 nM | BindingDB | SHOW | |
LGJ | Small Molecule | 3KQB | Ki : 0.5 nM | Binding MOAD | SHOW | |
LGK | Small Molecule | 3KQC | Ki : 2.2 nM | PDBBind | SHOW | |
LGK | Small Molecule | 3KQC | Ki : 2.2 nM | BindingDB | SHOW | |
LGK | Small Molecule | 3KQC | Ki : 2.2 nM | Binding MOAD | SHOW | |
LGL | Small Molecule | 3KQD | Ki : 0.4 nM | PDBBind | SHOW | |
LGL | Small Molecule | 3KQD | Ki : 0.4 nM | BindingDB | SHOW | |
IID | Small Molecule | 2BQ7 | Ki : 89.0 nM | PDBBind | SHOW | |
IID | Small Molecule | 2BQ7 | Ki : 89.0 nM | BindingDB | SHOW | |
IID | Small Molecule | 2BQ7 | Ki : 89.0 nM | Binding MOAD | SHOW | |
IIE | Small Molecule | 2BQW | Ki : 3.0 nM | PDBBind | SHOW | |
IIE | Small Molecule | 2BQW | Ki : 3.0 nM | BindingDB | SHOW | |
RPR | Small Molecule | 1EZQ | Ki : 0.9 nM | PDBBind | SHOW | |
RPR | Small Molecule | 1EZQ | Ki : 0.9 nM | BindingDB | SHOW | |
RPR | Small Molecule | 1EZQ | Ki : 0.9 nM | Binding MOAD | SHOW | |
815 | Small Molecule | 1F0R | Ki : 22.0 nM | PDBBind | SHOW | |
815 | Small Molecule | 1F0R | Ki : 22.0 nM | BindingDB | SHOW | |
815 | Small Molecule | 1F0R | Ki : 22.0 nM | Binding MOAD | SHOW | |
Z34 | Small Molecule | 1FJS | Ki : 0.11 nM | PDBBind | SHOW | |
Z34 | Small Molecule | 1FJS | Ki : 0.11 nM | BindingDB | SHOW | |
Z34 | Small Molecule | 1FJS | Ki : 0.11 nM | Binding MOAD | SHOW | |
FXV | Small Molecule | 1KSN | Ki : 0.4 nM | PDBBind | SHOW | |
FXV | Small Molecule | 1KSN | Ki : 0.4 nM | Binding MOAD | SHOW | |
RTR | Small Molecule | 1NFY | Ki : 1.0 nM, Ki : 1.3 nM | BindingDB | SHOW | |
RTR | Small Molecule | 1NFY | Ki : 1.3 nM | Binding MOAD | SHOW | |
FXI | Small Molecule | 2Q1J | IC50 : 0.8 nM | PDBBind | SHOW | |
FXI | Small Molecule | 2Q1J | IC50 : 0.8 nM | Binding MOAD | SHOW | |
XBV | Small Molecule | 2XBV | Kd : 3.7 nM | PDBBind | SHOW | |
XBV | Small Molecule | 2XBV | Kd : 3.7 nM | BindingDB | SHOW | |
XBV | Small Molecule | 2XBV | Ki : 7.0 nM | Binding MOAD | SHOW | |
RR8 | Small Molecule | 2XBX | Ki : 15.0 nM | PDBBind | SHOW | |
RR8 | Small Molecule | 2XBX | Ki : 15.0 nM | BindingDB | SHOW | |
RR8 | Small Molecule | 2XBX | Ki : 15.0 nM | Binding MOAD | SHOW | |
8NC | Small Molecule | 2XC0 | Ki : 192.0 nM | PDBBind | SHOW | |
8NC | Small Molecule | 2XC0 | Ki : 192.0 nM | BindingDB | SHOW | |
8NC | Small Molecule | 2XC0 | Ki : 192.0 nM | Binding MOAD | SHOW | |
BI7 | Small Molecule | 2JKH | Ki : 9.0 nM, Ki : 9.0 nM | Binding MOAD | SHOW | |
CBB | Small Molecule | 1LPK | Ki : 28.0 nM | PDBBind | SHOW | |
CBB | Small Molecule | 1LPK | Ki : 28.0 nM | Binding MOAD | SHOW | |
T87 | Small Molecule | 1G2L | Ki : 57.0 nM | PDBBind | SHOW | |
T87 | Small Molecule | 1G2L | Ki : 57.0 nM | BindingDB | SHOW | |
T87 | Small Molecule | 1G2L | Ki : 57.0 nM | Binding MOAD | SHOW | |
R11 | Small Molecule | 1G2M | Ki : 40.0 nM | PDBBind | SHOW | |
R11 | Small Molecule | 1G2M | Ki : 40.0 nM | BindingDB | SHOW | |
LZF | Small Molecule | 2VVC | Ki : 3.0 nM, Ki : 3000.0 nM | BindingDB | SHOW | |
H22 | Small Molecule | 2VVU | Ki : 8.0 nM | PDBBind | SHOW | |
H22 | Small Molecule | 2VVU | Ki : 8.0 nM | BindingDB | SHOW | |
784 | Small Molecule | 2BOK | Ki : 280.0 nM | PDBBind | SHOW | |
784 | Small Molecule | 2BOK | Ki : 280.0 nM | Binding MOAD | SHOW | |
XWG | Small Molecule | 2Y5F | Ki : 2.0 nM | PDBBind | SHOW | |
XWG | Small Molecule | 2Y5F | Ki : 2.0 nM | Binding MOAD | SHOW | |
FJD | Small Molecule | 2Y5G | Ki : 146.0 nM | PDBBind | SHOW | |
FJD | Small Molecule | 2Y5G | Ki : 146.0 nM | Binding MOAD | SHOW | |
Y5H | Small Molecule | 2Y5H | Ki : 1620.0 nM | PDBBind | SHOW | |
Y5H | Small Molecule | 2Y5H | Ki : 1620.0 nM | Binding MOAD | SHOW | |
IIA | Small Molecule | 2BOH | Ki : 3.0 nM | PDBBind | SHOW | |
IIA | Small Molecule | 2BOH | Ki : 3.0 nM | BindingDB | SHOW | |
IIA | Small Molecule | 2BOH | Ki : 3.0 nM | Binding MOAD | SHOW | |
IIB | Small Molecule | 2BQ6 | Ki : 0.07 nM | PDBBind | SHOW | |
IIB | Small Molecule | 2BQ6 | Ki : 0.07 nM | BindingDB | SHOW | |
898 | Small Molecule | 2WYJ | Ki : 1.0 nM, Ki : 0.8 nM | BindingDB | SHOW | |
898 | Small Molecule | 2WYJ | Ki : 1.0 nM | Binding MOAD | SHOW | |
MZA | Small Molecule | 2Y7X | Ki : 1.3 nM | PDBBind | SHOW | |
MZA | Small Molecule | 2Y7X | Ki : 1.3 nM | BindingDB | SHOW | |
MZA | Small Molecule | 2Y7X | Ki : 1.0 nM | Binding MOAD | SHOW | |
439 | Small Molecule | 2Y80 | Ki : 9.0 nM, Ki : 3.0 nM | BindingDB | SHOW | |
439 | Small Molecule | 2Y80 | Ki : 9.0 nM | Binding MOAD | SHOW | |
IMA | Small Molecule | 1LPG | Ki : 82.0 nM | PDBBind | SHOW | |
IMA | Small Molecule | 1LPG | Ki : 82.0 nM | BindingDB | SHOW | |
IMA | Small Molecule | 1LPG | Ki : 82.0 nM | Binding MOAD | SHOW | |
DX9 | Small Molecule | 1FAX | Ki : 41.0 nM, Ki : 40.0 nM, Ki : 22.0 nM, Ki : 20.0 nM, Ki : 40.0 nM, IC50 : 70.0 nM, IC50 : 130.0 nM | BindingDB | SHOW | |
LG0 | Small Molecule | 3CS7 | Ki : 0.021 nM | PDBBind | SHOW | |
LG0 | Small Molecule | 3CS7 | Ki : 0.02 nM | BindingDB | SHOW | |
LG0 | Small Molecule | 3CS7 | Ki : 0.021 nM | Binding MOAD | SHOW | |
D90 | Small Molecule | 3Q3K | IC50 : 7.4 nM | PDBBind | SHOW | |
D90 | Small Molecule | 3Q3K | IC50 : 7.4 nM | BindingDB | SHOW | |
D90 | Small Molecule | 3Q3K | IC50 : 7.4 nM | Binding MOAD | SHOW | |
993 | Small Molecule | 2P3T | Ki : 0.0 nM, Ki : 0.06 nM | BindingDB | SHOW | |
993 | Small Molecule | 2P3T | Ki : 0.005 nM | Binding MOAD | SHOW | |
48U | Small Molecule | 4Y6D | Ki : 1.5 nM, Ki : 4.83 nM | BindingDB | SHOW | |
OYJ | Small Molecule | 2XC5 | Ki : 62.0 nM | BindingDB | SHOW | |
OYJ | Small Molecule | 2XC5 | Ki : 62.0 nM | Binding MOAD | SHOW | |
237 | Small Molecule | 2PR3 | IC50 : 0.16 nM, IC50 : 1.7 nM | BindingDB | SHOW | |
237 | Small Molecule | 2PR3 | IC50 : 0.16 nM | Binding MOAD | SHOW | |
D1Q | Small Molecule | 3TK5 | IC50 : 1.3 nM | BindingDB | SHOW | |
D46 | Small Molecule | 3TK6 | IC50 : 1.7 nM | BindingDB | SHOW | |
XMH | Small Molecule | 1IQJ |
- |
- |
SHOW | |
63C | Small Molecule | 2XBY |
- |
- |
SHOW | |
XMG | Small Molecule | 1IQI |
- |
- |
SHOW | |
44I | Small Molecule | 4Y7B |
- |
- |
SHOW | |
930 | Small Molecule | 2Y82 |
- |
- |
SHOW | |
D01 | Small Molecule | 2D1J |
- |
- |
SHOW | |
XMA | Small Molecule | 1IOE |
- |
- |
SHOW | |
6PK | Small Molecule | 5K0H |
- |
- |
SHOW | |
4O1 | Small Molecule | 4Y76 |
- |
- |
SHOW | |
663 | Small Molecule | 2P3U |
- |
- |
SHOW | |
XMI | Small Molecule | 1IQK |
- |
- |
SHOW | |
XMD | Small Molecule | 1IQF |
- |
- |
SHOW | |
XMC | Small Molecule | 1IQN |
- |
- |
SHOW | |
XMF | Small Molecule | 1IQH |
- |
- |
SHOW | |
4O5 | Small Molecule | 4ZHA |
- |
- |
SHOW | |
XME | Small Molecule | 1IQG |
- |
- |
SHOW | |
455 | Small Molecule | 2XBW |
- |
- |
SHOW |