Protein

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Protein Name Coagulation factor X
#PDB ID 85
Organism Homo sapiens
Uniprot ID/ACC P00742 (FA10_HUMAN)
Protein Sequence MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Protein Class HYDROLASE
Synonym(s)
  •   coagulation factor X
  • Stuart-Prower factor
  • factor X
  • factor Xa
  • prothrombinase
  • FX
  • FXA
show 6 synonym(s)
Gene Symbol F10
Gene ID 2159
Pfam ID PF00008, PF00594, PF00089
Interpro ID IPR017857, IPR001881, IPR000742, IPR000152, IPR018097, IPR035972, IPR000294, IPR012224, IPR009003, IPR043504, IPR001314, IPR001254, IPR018114, IPR033116
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
XLD Small Molecule 1MQ6 Ki : 0.01 nM, Ki : 0.29 nM BindingDB SHOW
XLD Small Molecule 1MQ6 Ki : 0.007 nM Binding MOAD SHOW
RDR Small Molecule 1NFX Ki : 3.0 nM PDBBind SHOW
RDR Small Molecule 1NFX Ki : 3.0 nM BindingDB SHOW
RDR Small Molecule 1NFX Ki : 3.0 nM Binding MOAD SHOW
RRR Small Molecule 1NFW Ki : 1.1 nM PDBBind SHOW
RRR Small Molecule 1NFW Ki : 1.1 nM BindingDB SHOW
RRR Small Molecule 1NFW Ki : 1.1 nM Binding MOAD SHOW
PR2 Small Molecule 1F0S Ki : 18.0 nM PDBBind SHOW
PR2 Small Molecule 1F0S Ki : 18.0 nM BindingDB SHOW
PR2 Small Molecule 1F0S Ki : 18.0 nM Binding MOAD SHOW
4PP Small Molecule 1XKA IC50 : 270.0 nM, IC50 : 2.7 nM BindingDB SHOW
4PP Small Molecule 1XKA Ki : 131.0 nM Binding MOAD SHOW
931 Small Molecule 2Y81 Ki : 2.0 nM PDBBind SHOW
931 Small Molecule 2Y81 Ki : 2.0 nM BindingDB SHOW
931 Small Molecule 2Y81 Ki : 2.0 nM Binding MOAD SHOW
D14 Small Molecule 3IIT IC50 : 9.5 nM, IC50 : 9.5 nM Binding MOAD SHOW
I1H Small Molecule 2BMG Ki : 18.0 nM PDBBind SHOW
I1H Small Molecule 2BMG Ki : 18.0 nM BindingDB SHOW
230 Small Molecule 2PHB IC50 : 0.32 nM, IC50 : 0.57 nM BindingDB SHOW
230 Small Molecule 2PHB IC50 : 0.32 nM Binding MOAD SHOW
RIV Small Molecule 2W26 Ki : 0.66 nM, Ki : 0.4 nM, Ki : 1.6 nM, Ki : 8.5 nM, Ki : 0.7 nM, Ki : 2.2 nM, Ki : 4.59 nM, Ki : 400.0 nM, Ki : 1.4 nM, Ki : 14.0 nM, Ki : 700.0 nM BindingDB SHOW
RIV Small Molecule 2W26 Ki : 0.4 nM Binding MOAD SHOW
LZG Small Molecule 2VWO Ki : 31.0 nM PDBBind SHOW
LZG Small Molecule 2VWO Ki : 31.0 nM BindingDB SHOW
CMB Small Molecule 1LPZ Ki : 25.0 nM PDBBind SHOW
CMB Small Molecule 1LPZ Ki : 25.0 nM BindingDB SHOW
CMB Small Molecule 1LPZ Ki : 25.0 nM Binding MOAD SHOW
CMI Small Molecule 1LQD Ki : 9.0 nM PDBBind SHOW
CMI Small Molecule 1LQD Ki : 9.0 nM BindingDB SHOW
5QC Small Molecule 2FZZ Ki : 0.03 nM PDBBind SHOW
5QC Small Molecule 2FZZ Ki : 0.03 nM BindingDB SHOW
5QC Small Molecule 2FZZ Ki : 0.03 nM Binding MOAD SHOW
IK8 Small Molecule 1Z6E Ki : 0.19 nM, Ki : 1.6 nM BindingDB SHOW
IK8 Small Molecule 1Z6E Ki : 0.19 nM Binding MOAD SHOW
M37 Small Molecule 3M37 Ki : 0.91 nM, Ki : 2.9 nM BindingDB SHOW
XLC Small Molecule 1MQ5 Ki : 0.76 nM, Ki : 1.0 nM BindingDB SHOW
XLC Small Molecule 1MQ5 Ki : 1.0 nM Binding MOAD SHOW
FXA Small Molecule 3CEN Ki : 5.5 nM PDBBind SHOW
FXA Small Molecule 3CEN Ki : 5.5 nM BindingDB SHOW
FXA Small Molecule 3CEN Ki : 5.5 nM Binding MOAD SHOW
L1C Small Molecule 2W3I IC50 : 0.1 nM, IC50 : 1.32 nM BindingDB SHOW
L1C Small Molecule 2W3I IC50 : 0.1 nM Binding MOAD SHOW
L1D Small Molecule 2W3K IC50 : 0.08 nM PDBBind SHOW
L1D Small Molecule 2W3K IC50 : 0.08 nM BindingDB SHOW
L1D Small Molecule 2W3K IC50 : 0.08 nM Binding MOAD SHOW
D91 Small Molecule 1WU1 IC50 : 18.0 nM PDBBind SHOW
D91 Small Molecule 1WU1 IC50 : 18.0 nM Binding MOAD SHOW
C0Z Small Molecule 2Y7Z Ki : 2.0 nM PDBBind SHOW
C0Z Small Molecule 2Y7Z Ki : 2.0 nM BindingDB SHOW
C0Z Small Molecule 2Y7Z Ki : 2.0 nM Binding MOAD SHOW
ME1 Small Molecule 2P93 Ki : 1.5 nM PDBBind SHOW
ME1 Small Molecule 2P93 Ki : 1.5 nM BindingDB SHOW
ME1 Small Molecule 2P93 Ki : 1.5 nM Binding MOAD SHOW
D76 Small Molecule 1V3X IC50 : 24.0 nM PDBBind SHOW
D76 Small Molecule 1V3X IC50 : 24.0 nM BindingDB SHOW
D76 Small Molecule 1V3X IC50 : 24.0 nM Binding MOAD SHOW
ME4 Small Molecule 2P94 Ki : 0.67 nM PDBBind SHOW
ME4 Small Molecule 2P94 Ki : 0.67 nM BindingDB SHOW
ME4 Small Molecule 2P94 Ki : 0.67 nM Binding MOAD SHOW
ME5 Small Molecule 2P95 Ki : 0.43 nM PDBBind SHOW
ME5 Small Molecule 2P95 Ki : 0.43 nM BindingDB SHOW
ME5 Small Molecule 2P95 Ki : 0.43 nM Binding MOAD SHOW
JNJ Small Molecule 2RA0 Ki : 15.9 nM PDBBind SHOW
JNJ Small Molecule 2RA0 Ki : 15.9 nM BindingDB SHOW
JNJ Small Molecule 2RA0 Ki : 15.9 nM Binding MOAD SHOW
A7I Small Molecule 4A7I Ki : 2.0 nM PDBBind SHOW
A7I Small Molecule 4A7I Ki : 2.0 nM Binding MOAD SHOW
FFG Small Molecule 3FFG Ki : 0.84 nM PDBBind SHOW
FFG Small Molecule 3FFG Ki : 0.84 nM BindingDB SHOW
FFG Small Molecule 3FFG Ki : 0.84 nM Binding MOAD SHOW
LGJ Small Molecule 3KQB Ki : 0.5 nM PDBBind SHOW
LGJ Small Molecule 3KQB Ki : 0.5 nM BindingDB SHOW
LGJ Small Molecule 3KQB Ki : 0.5 nM Binding MOAD SHOW
LGK Small Molecule 3KQC Ki : 2.2 nM PDBBind SHOW
LGK Small Molecule 3KQC Ki : 2.2 nM BindingDB SHOW
LGK Small Molecule 3KQC Ki : 2.2 nM Binding MOAD SHOW
LGL Small Molecule 3KQD Ki : 0.4 nM PDBBind SHOW
LGL Small Molecule 3KQD Ki : 0.4 nM BindingDB SHOW
IID Small Molecule 2BQ7 Ki : 89.0 nM PDBBind SHOW
IID Small Molecule 2BQ7 Ki : 89.0 nM BindingDB SHOW
IID Small Molecule 2BQ7 Ki : 89.0 nM Binding MOAD SHOW
IIE Small Molecule 2BQW Ki : 3.0 nM PDBBind SHOW
IIE Small Molecule 2BQW Ki : 3.0 nM BindingDB SHOW
RPR Small Molecule 1EZQ Ki : 0.9 nM PDBBind SHOW
RPR Small Molecule 1EZQ Ki : 0.9 nM BindingDB SHOW
RPR Small Molecule 1EZQ Ki : 0.9 nM Binding MOAD SHOW
815 Small Molecule 1F0R Ki : 22.0 nM PDBBind SHOW
815 Small Molecule 1F0R Ki : 22.0 nM BindingDB SHOW
815 Small Molecule 1F0R Ki : 22.0 nM Binding MOAD SHOW
Z34 Small Molecule 1FJS Ki : 0.11 nM PDBBind SHOW
Z34 Small Molecule 1FJS Ki : 0.11 nM BindingDB SHOW
Z34 Small Molecule 1FJS Ki : 0.11 nM Binding MOAD SHOW
FXV Small Molecule 1KSN Ki : 0.4 nM PDBBind SHOW
FXV Small Molecule 1KSN Ki : 0.4 nM Binding MOAD SHOW
RTR Small Molecule 1NFY Ki : 1.0 nM, Ki : 1.3 nM BindingDB SHOW
RTR Small Molecule 1NFY Ki : 1.3 nM Binding MOAD SHOW
FXI Small Molecule 2Q1J IC50 : 0.8 nM PDBBind SHOW
FXI Small Molecule 2Q1J IC50 : 0.8 nM Binding MOAD SHOW
XBV Small Molecule 2XBV Kd : 3.7 nM PDBBind SHOW
XBV Small Molecule 2XBV Kd : 3.7 nM BindingDB SHOW
XBV Small Molecule 2XBV Ki : 7.0 nM Binding MOAD SHOW
RR8 Small Molecule 2XBX Ki : 15.0 nM PDBBind SHOW
RR8 Small Molecule 2XBX Ki : 15.0 nM BindingDB SHOW
RR8 Small Molecule 2XBX Ki : 15.0 nM Binding MOAD SHOW
8NC Small Molecule 2XC0 Ki : 192.0 nM PDBBind SHOW
8NC Small Molecule 2XC0 Ki : 192.0 nM BindingDB SHOW
8NC Small Molecule 2XC0 Ki : 192.0 nM Binding MOAD SHOW
BI7 Small Molecule 2JKH Ki : 9.0 nM, Ki : 9.0 nM Binding MOAD SHOW
CBB Small Molecule 1LPK Ki : 28.0 nM PDBBind SHOW
CBB Small Molecule 1LPK Ki : 28.0 nM Binding MOAD SHOW
T87 Small Molecule 1G2L Ki : 57.0 nM PDBBind SHOW
T87 Small Molecule 1G2L Ki : 57.0 nM BindingDB SHOW
T87 Small Molecule 1G2L Ki : 57.0 nM Binding MOAD SHOW
R11 Small Molecule 1G2M Ki : 40.0 nM PDBBind SHOW
R11 Small Molecule 1G2M Ki : 40.0 nM BindingDB SHOW
LZF Small Molecule 2VVC Ki : 3.0 nM, Ki : 3000.0 nM BindingDB SHOW
H22 Small Molecule 2VVU Ki : 8.0 nM PDBBind SHOW
H22 Small Molecule 2VVU Ki : 8.0 nM BindingDB SHOW
784 Small Molecule 2BOK Ki : 280.0 nM PDBBind SHOW
784 Small Molecule 2BOK Ki : 280.0 nM Binding MOAD SHOW
XWG Small Molecule 2Y5F Ki : 2.0 nM PDBBind SHOW
XWG Small Molecule 2Y5F Ki : 2.0 nM Binding MOAD SHOW
FJD Small Molecule 2Y5G Ki : 146.0 nM PDBBind SHOW
FJD Small Molecule 2Y5G Ki : 146.0 nM Binding MOAD SHOW
Y5H Small Molecule 2Y5H Ki : 1620.0 nM PDBBind SHOW
Y5H Small Molecule 2Y5H Ki : 1620.0 nM Binding MOAD SHOW
IIA Small Molecule 2BOH Ki : 3.0 nM PDBBind SHOW
IIA Small Molecule 2BOH Ki : 3.0 nM BindingDB SHOW
IIA Small Molecule 2BOH Ki : 3.0 nM Binding MOAD SHOW
IIB Small Molecule 2BQ6 Ki : 0.07 nM PDBBind SHOW
IIB Small Molecule 2BQ6 Ki : 0.07 nM BindingDB SHOW
898 Small Molecule 2WYJ Ki : 1.0 nM, Ki : 0.8 nM BindingDB SHOW
898 Small Molecule 2WYJ Ki : 1.0 nM Binding MOAD SHOW
MZA Small Molecule 2Y7X Ki : 1.3 nM PDBBind SHOW
MZA Small Molecule 2Y7X Ki : 1.3 nM BindingDB SHOW
MZA Small Molecule 2Y7X Ki : 1.0 nM Binding MOAD SHOW
439 Small Molecule 2Y80 Ki : 9.0 nM, Ki : 3.0 nM BindingDB SHOW
439 Small Molecule 2Y80 Ki : 9.0 nM Binding MOAD SHOW
IMA Small Molecule 1LPG Ki : 82.0 nM PDBBind SHOW
IMA Small Molecule 1LPG Ki : 82.0 nM BindingDB SHOW
IMA Small Molecule 1LPG Ki : 82.0 nM Binding MOAD SHOW
DX9 Small Molecule 1FAX Ki : 41.0 nM, Ki : 40.0 nM, Ki : 22.0 nM, Ki : 20.0 nM, Ki : 40.0 nM, IC50 : 70.0 nM, IC50 : 130.0 nM BindingDB SHOW
LG0 Small Molecule 3CS7 Ki : 0.021 nM PDBBind SHOW
LG0 Small Molecule 3CS7 Ki : 0.02 nM BindingDB SHOW
LG0 Small Molecule 3CS7 Ki : 0.021 nM Binding MOAD SHOW
D90 Small Molecule 3Q3K IC50 : 7.4 nM PDBBind SHOW
D90 Small Molecule 3Q3K IC50 : 7.4 nM BindingDB SHOW
D90 Small Molecule 3Q3K IC50 : 7.4 nM Binding MOAD SHOW
993 Small Molecule 2P3T Ki : 0.0 nM, Ki : 0.06 nM BindingDB SHOW
993 Small Molecule 2P3T Ki : 0.005 nM Binding MOAD SHOW
48U Small Molecule 4Y6D Ki : 1.5 nM, Ki : 4.83 nM BindingDB SHOW
OYJ Small Molecule 2XC5 Ki : 62.0 nM BindingDB SHOW
OYJ Small Molecule 2XC5 Ki : 62.0 nM Binding MOAD SHOW
237 Small Molecule 2PR3 IC50 : 0.16 nM, IC50 : 1.7 nM BindingDB SHOW
237 Small Molecule 2PR3 IC50 : 0.16 nM Binding MOAD SHOW
D1Q Small Molecule 3TK5 IC50 : 1.3 nM BindingDB SHOW
D46 Small Molecule 3TK6 IC50 : 1.7 nM BindingDB SHOW
XMH Small Molecule 1IQJ
-
-
SHOW
63C Small Molecule 2XBY
-
-
SHOW
XMG Small Molecule 1IQI
-
-
SHOW
44I Small Molecule 4Y7B
-
-
SHOW
930 Small Molecule 2Y82
-
-
SHOW
D01 Small Molecule 2D1J
-
-
SHOW
XMA Small Molecule 1IOE
-
-
SHOW
6PK Small Molecule 5K0H
-
-
SHOW
4O1 Small Molecule 4Y76
-
-
SHOW
663 Small Molecule 2P3U
-
-
SHOW
XMI Small Molecule 1IQK
-
-
SHOW
XMD Small Molecule 1IQF
-
-
SHOW
XMC Small Molecule 1IQN
-
-
SHOW
XMF Small Molecule 1IQH
-
-
SHOW
4O5 Small Molecule 4ZHA
-
-
SHOW
XME Small Molecule 1IQG
-
-
SHOW
455 Small Molecule 2XBW
-
-
SHOW