301 complex(es)
PDB ID
Protein Name
Organism
Uniprot ID/ACC
Ligand Name
HET ID
Structure
PS-Score (Pocket Similarity)
Card
1 5FP8 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 3-[(4-methylthiophen-2-yl)methylamino]pyridine-4-carboxylic acid AUY 0.91 SHOW
2 6H0Y Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) (2~{R})-3-(4-methoxyphenyl)-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide FHZ 0.78 SHOW
3 6H0X Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) [[(2~{R})-2-(5-phenylpentanoylamino)-2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoyl]amino]azanium FJB 0.74 SHOW
4 5FPB Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 2-(1H-pyrazol-4-yloxy)-3H-pyrido[3,4-d]pyrimidin-4-one HA6 0.72 SHOW
5 6F5Q Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 2-[2-(methylsulfonylamino)ethylamino]pyridine-4-carboxylic acid CTK 0.72 SHOW
6 6CG1 Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 3-{[(4-fluorophenyl)methyl]amino}pyridine-4-carboxylic acid QC1 0.7 SHOW
7 6DQE Lysine-specific demethylase 5A Homo sapiens P29375 (KDM5A_HUMAN) 2-(5-phenyl-4-{(R)-phenyl[2-(piperidin-1-yl)ethoxy]methyl}-1H-pyrazol-1-yl)pyridine-4-carboxylic acid H6A 0.67 SHOW
8 5FP7 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 3-(4-phenylbutanoylamino)pyridine-4-carboxylic acid YC8 0.67 SHOW
9 5FP4 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 3-(4-phenylbutanoylamino)pyridine-4-carboxylic acid YC8 0.67 SHOW
10 6H0W Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) (2~{R})-3-phenyl-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide FHW 0.65 SHOW
11 4D6Q Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) PYRIDINE-2,4-DICARBOXYLIC ACID PD2 0.65 SHOW
12 6H11 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) [[(2~{R})-2-[(4-bromophenyl)carbonylamino]-2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoyl]amino]azanium FHT 0.64 SHOW
13 6F5R Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 2-(3-oxidanylpropylamino)pyridine-4-carboxylic acid CQZ 0.64 SHOW
14 6F5T Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) ~{N}-oxidanyl-4-(2~{H}-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide CQK 0.6 SHOW
15 6H4P Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-[2-[4-(3-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FQ5 0.59 SHOW
16 6H4S Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-[2-[4-[3-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FQE 0.56 SHOW
17 6H4Y Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-[2-[4-[4-(2-morpholin-4-ylethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FO8 0.56 SHOW
18 6H4T Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-(2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethyl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FOW 0.56 SHOW
19 6H4V Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-(1-cyclopentylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FQN 0.56 SHOW
20 6ETG Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) [[4-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]carbonylamino]azanium BWT 0.56 SHOW
21 6H4O Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-[2-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FQH 0.56 SHOW
22 6H4U Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FO2 0.55 SHOW
23 6DQ7 Lysine-specific demethylase 5A Homo sapiens P29375 (KDM5A_HUMAN) N-{6-[4-(hydroxyacetyl)-1,4-diazepan-1-yl]-2-(pyridin-2-yl)pyrimidin-4-yl}-beta-alanine H6M 0.55 SHOW
24 6DQC Lysine-specific demethylase 5A Homo sapiens P29375 (KDM5A_HUMAN) 2-[4-{[2-(dimethylamino)ethyl](ethyl)carbamoyl}-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid H5Y 0.55 SHOW
25 6H4W Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-[2-[4-(3-chlorophenyl)-4-methyl-piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FQQ 0.54 SHOW
26 6H4X Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-[2-[4-(4-pyridin-3-ylphenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FNQ 0.54 SHOW
27 5FPA Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 3H-pyrido[3,4-d]pyrimidin-4-one N5J 0.52 SHOW
28 6DQF Lysine-specific demethylase 5A Homo sapiens P29375 (KDM5A_HUMAN) 2-{1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-yl}thieno[3,2-b]pyridine-7-carboxylic acid H61 0.51 SHOW
29 5FZH Lysine-specific demethylase 5B Homo sapiens Q9UGL1 (KDM5B_HUMAN) (3R)-5-fluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one 0TI 0.51 SHOW
30 6H4R Lysine-specific demethylase 4A Homo sapiens O75164 (KDM4A_HUMAN) 8-[4-[2-[4-[4-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one FQB 0.5 SHOW
31 5CEH Lysine-specific demethylase 5A Homo sapiens P29375 (KDM5A_HUMAN) 7-oxo-5-phenyl-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 50P 0.49 SHOW
32 5FYU Lysine-specific demethylase 5B Homo sapiens Q9UGL1 (KDM5B_HUMAN) (3R)-3-azanyl-4-methyl-1,3-dihydroindol-2-one BY4 0.49 SHOW
33 6ETW Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) [4-(2~{H}-1,2,3,4-tetrazol-5-yl)butanoylamino]azanium BX5 0.49 SHOW
34 5F5C Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 8-[[(phenylmethyl)amino]methyl]-1~{H}-pyrido[3,4-d]pyrimidin-4-one 5V3 0.49 SHOW
35 6ETU Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) [[3-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]carbonylamino]azanium BWZ 0.49 SHOW
36 2W2I Lysine-specific demethylase 4E Homo sapiens B2RXH2 (KDM4E_HUMAN) PYRIDINE-2,4-DICARBOXYLIC ACID PD2 0.49 SHOW
37 6EIU Lysine-specific demethylase 5B Homo sapiens Q9UGL1 (KDM5B_HUMAN) 8-oxidanyl-6-phenyl-7-propan-2-yl-imidazo[1,2-b]pyridazine-3-carbonitrile B6T 0.47 SHOW
38 6F5S Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) ~{N}-(3-morpholin-4-ylpropyl)-4-(2~{H}-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide CQT 0.47 SHOW
39 5LWB Lysine-specific demethylase 5B Homo sapiens Q9UGL1 (KDM5B_HUMAN) 5-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-7-oxidanylidene-6-propan-2-yl-6~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile 79H 0.46 SHOW
40 5F5A Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) 2-[(furan-2-ylmethylamino)methyl]pyridine-4-carboxylic acid 5V0 0.46 SHOW
41 6ETS Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) [2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoylamino]azanium I1L 0.45 SHOW
42 5PL3 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) N-OXALYLGLYCINE OGA 0.45 SHOW
43 5PNF Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) N-OXALYLGLYCINE OGA 0.45 SHOW
44 6BH4 Lysine-specific demethylase 5A Homo sapiens P29375 (KDM5A_HUMAN) 5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile DQS 0.45 SHOW
45 6H10 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) ~{N}-[(~{E})-(4-methylphenyl)methylideneamino]-2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanamide FJ8 0.45 SHOW
46 5PNU Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) N-OXALYLGLYCINE OGA 0.45 SHOW
47 5PMA Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) N-OXALYLGLYCINE OGA 0.45 SHOW
48 5PN8 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) N-OXALYLGLYCINE OGA 0.45 SHOW
49 5PLO Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) N-OXALYLGLYCINE OGA 0.45 SHOW
50 5PL4 Lysine-specific demethylase 4D Homo sapiens Q6B0I6 (KDM4D_HUMAN) N-OXALYLGLYCINE OGA 0.45 SHOW