Protein

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Protein Name Lysine-specific demethylase 4D
#PDB ID 276
Organism Homo sapiens
Uniprot ID/ACC Q6B0I6 (KDM4D_HUMAN)
Protein Sequence METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
Protein Class TRANSCRIPTION REGULATOR
Synonym(s)
  •   lysine-specific demethylase 4D
  • [histone H3]-trimethyl-L-lysine(9) demethylase 4D
  • jmjC domain-containing histone demethylation protein 3D
  • jumonji domain containing 2D
  • jumonji domain-containing protein 2D
  • lysine (K)-specific demethylase 4D
  • JMJD2D
show 6 synonym(s)
Gene Symbol KDM4D
Gene ID 55693
Pfam ID PF02373, PF02375
Interpro ID IPR003347, IPR003349
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
YC8 Small Molecule 5FP7 IC50 : 251.0 nM BindingDB SHOW
4SV Small Molecule 5FP9 IC50 : 1259.0 nM, IC50 : 1585.0 nM BindingDB SHOW
4SV Small Molecule 5FP9 IC50 : 1585.0 nM Binding MOAD SHOW
YC8 Small Molecule 5FP4 IC50 : 251.0 nM BindingDB SHOW
YC8 Small Molecule 5FP4 IC50 : 251.0 nM Binding MOAD SHOW
OGA Small Molecule 5PLA
-
-
SHOW
OGA Small Molecule 5PH5
-
-
SHOW
OGA Small Molecule 5PMQ
-
-
SHOW
OGA Small Molecule 5PKP
-
-
SHOW
OGA Small Molecule 5PL0
-
-
SHOW
OGA Small Molecule 5PKV
-
-
SHOW
OGA Small Molecule 5PHY
-
-
SHOW
OGA Small Molecule 5PLC
-
-
SHOW
OGA Small Molecule 5PH6
-
-
SHOW
OGA Small Molecule 5PKU
-
-
SHOW
OGA Small Molecule 5PKR
-
-
SHOW
OGA Small Molecule 5PLU
-
-
SHOW
OGA Small Molecule 5PKE
-
-
SHOW
OGA Small Molecule 4D6R
-
-
SHOW
OGA Small Molecule 5PMU
-
-
SHOW
OGA Small Molecule 5PNJ
-
-
SHOW
FHZ Small Molecule 6H0Y
-
-
SHOW
OGA Small Molecule 5PKB
-
-
SHOW
OGA Small Molecule 5PIA
-
-
SHOW
OGA Small Molecule 5PL1
-
-
SHOW
OGA Small Molecule 5PMD
-
-
SHOW
OGA Small Molecule 5PJI
-
-
SHOW
OGA Small Molecule 5PIL
-
-
SHOW
OGA Small Molecule 5PIR
-
-
SHOW
OGA Small Molecule 5PJX
-
-
SHOW
OGA Small Molecule 5PJU
-
-
SHOW
OGA Small Molecule 5PJQ
-
-
SHOW
OGA Small Molecule 5PI8
-
-
SHOW
BWT Small Molecule 6ETG
-
-
SHOW
OGA Small Molecule 5PM4
-
-
SHOW
OGA Small Molecule 5PMS
-
-
SHOW
OGA Small Molecule 5PJ2
-
-
SHOW
OGA Small Molecule 5PMI
-
-
SHOW
OGA Small Molecule 5PIM
-
-
SHOW
OGA Small Molecule 5PJR
-
-
SHOW
OGA Small Molecule 5PLD
-
-
SHOW
OGA Small Molecule 5PII
-
-
SHOW
OGA Small Molecule 5PJE
-
-
SHOW
OGA Small Molecule 5PLE
-
-
SHOW
OGA Small Molecule 5PLI
-
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SHOW
OGA Small Molecule 5PNC
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SHOW
OGA Small Molecule 5PHV
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-
SHOW
OGA Small Molecule 5PI2
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-
SHOW
BWZ Small Molecule 6ETU
-
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SHOW
OGA Small Molecule 5PMN
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SHOW
OGA Small Molecule 5PHH
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SHOW
OGA Small Molecule 5PK6
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SHOW
OGA Small Molecule 5PN1
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SHOW
OGA Small Molecule 5PMH
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SHOW
OGA Small Molecule 5PMO
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SHOW
OGA Small Molecule 5PNO
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-
SHOW
OGA Small Molecule 5PND
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-
SHOW
OGA Small Molecule 5PHX
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SHOW
OGA Small Molecule 5PIB
-
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SHOW
OGA Small Molecule 5PI7
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-
SHOW
HA6 Small Molecule 5FPB
-
-
SHOW
OGA Small Molecule 5PJ1
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SHOW
OGA Small Molecule 5PLK
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SHOW
OGA Small Molecule 5PJJ
-
-
SHOW
OGA Small Molecule 5PLB
-
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SHOW
OGA Small Molecule 5PI6
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SHOW
OGA Small Molecule 5PIU
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SHOW
OGA Small Molecule 5PHS
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-
SHOW
OGA Small Molecule 4D6S
-
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SHOW
OGA Small Molecule 5PM8
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SHOW
OGA Small Molecule 5PMW
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SHOW
OGA Small Molecule 5PJS
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SHOW
OGA Small Molecule 5PIZ
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SHOW
OGA Small Molecule 5PJF
-
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SHOW
OGA Small Molecule 5PMY
-
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SHOW
OGA Small Molecule 5PMR
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SHOW
OGA Small Molecule 5PMM
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SHOW
OGA Small Molecule 5PLZ
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SHOW
OGA Small Molecule 5PLW
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SHOW
OGA Small Molecule 5PKW
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SHOW
OGA Small Molecule 5PNP
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SHOW
OGA Small Molecule 5PKA
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-
SHOW
FJB Small Molecule 6H0X
-
-
SHOW
OGA Small Molecule 5PLT
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SHOW
OGA Small Molecule 5PH2
-
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SHOW
FHW Small Molecule 6H0W
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SHOW
OGA Small Molecule 5PIE
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SHOW
OGA Small Molecule 5PHM
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SHOW
OGA Small Molecule 5PJ7
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SHOW
OGA Small Molecule 5PL7
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SHOW
OGA Small Molecule 5PKZ
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-
SHOW
OGA Small Molecule 5PH9
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SHOW
OGA Small Molecule 5PN9
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-
SHOW
OGA Small Molecule 5PMZ
-
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SHOW
OGA Small Molecule 5PN8
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-
SHOW
OGA Small Molecule 5PIN
-
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SHOW
OGA Small Molecule 5PK5
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-
SHOW
OGA Small Molecule 5PJO
-
-
SHOW
BXH Small Molecule 6ETT
-
-
SHOW
OGA Small Molecule 5PM2
-
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SHOW
OGA Small Molecule 5PMG
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SHOW
OGA Small Molecule 5PJH
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SHOW
OGA Small Molecule 5PMP
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SHOW
OGA Small Molecule 5PHN
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SHOW
OGA Small Molecule 5PML
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SHOW
OGA Small Molecule 5PM3
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SHOW
OGA Small Molecule 5PIV
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SHOW
OGA Small Molecule 5PN6
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SHOW
OGA Small Molecule 5PLY
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SHOW
OGA Small Molecule 5PHI
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SHOW
OGA Small Molecule 5PLF
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-
SHOW
OGA Small Molecule 5PHF
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SHOW
OGA Small Molecule 5PNM
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SHOW
OGA Small Molecule 5PK8
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SHOW
OGA Small Molecule 5PKY
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SHOW
OGA Small Molecule 5PHE
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SHOW
OGA Small Molecule 5PKD
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-
SHOW
OGA Small Molecule 5PNK
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SHOW
FHT Small Molecule 6H11
-
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SHOW
OGA Small Molecule 5PI4
-
-
SHOW
OGA Small Molecule 5PNF
-
-
SHOW
CQZ Small Molecule 6F5R
-
-
SHOW
OGA Small Molecule 5PMK
-
-
SHOW
OGA Small Molecule 5PIK
-
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SHOW
OGA Small Molecule 5PMC
-
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SHOW
OGA Small Molecule 5PMJ
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SHOW
PD2 Small Molecule 4D6Q
-
-
SHOW
OGA Small Molecule 5PJT
-
-
SHOW
OGA Small Molecule 5PI3
-
-
SHOW
OGA Small Molecule 5PJM
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-
SHOW
OGA Small Molecule 5PHL
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-
SHOW
OGA Small Molecule 5PIX
-
-
SHOW
OGA Small Molecule 5PJK
-
-
SHOW
OGA Small Molecule 5PLN
-
-
SHOW
OGA Small Molecule 5PH4
-
-
SHOW
OGA Small Molecule 5PLR
-
-
SHOW
5V0 Small Molecule 5F5A
-
-
SHOW
OGA Small Molecule 5PLH
-
-
SHOW
OGA Small Molecule 5PKG
-
-
SHOW
OGA Small Molecule 5PKI
-
-
SHOW
OGA Small Molecule 5PKS
-
-
SHOW
OGA Small Molecule 5PIG
-
-
SHOW
OGA Small Molecule 5PJ4
-
-
SHOW
OGA Small Molecule 5PM5
-
-
SHOW
CQK Small Molecule 6F5T
-
-
SHOW
OGA Small Molecule 5PNN
-
-
SHOW
OGA Small Molecule 5PLX
-
-
SHOW
OGA Small Molecule 5PIW
-
-
SHOW
OGA Small Molecule 5PHG
-
-
SHOW
OGA Small Molecule 5PJD
-
-
SHOW
N5J Small Molecule 5FPA
-
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SHOW
OGA Small Molecule 5PKQ
-
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SHOW
OGA Small Molecule 5PM9
-
-
SHOW
AUY Small Molecule 5FP8
-
-
SHOW
OGA Small Molecule 5PKK
-
-
SHOW
OGA Small Molecule 5PI5
-
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SHOW
OGA Small Molecule 5PMA
-
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SHOW
OGA Small Molecule 5PH7
-
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SHOW
OGA Small Molecule 5PNG
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SHOW
OGA Small Molecule 5PJ8
-
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SHOW
OGA Small Molecule 5PH3
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SHOW
OGA Small Molecule 5PHD
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SHOW
OGA Small Molecule 5PJ9
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SHOW
OGA Small Molecule 5PM7
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SHOW
OGA Small Molecule 5PNS
-
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SHOW
OGA Small Molecule 5PMT
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SHOW
OGA Small Molecule 5PN2
-
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SHOW
OGA Small Molecule 5PI1
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SHOW
OGA Small Molecule 5PKJ
-
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SHOW
OGA Small Molecule 5PJ3
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SHOW
OGA Small Molecule 5PIO
-
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SHOW
OGA Small Molecule 5PHK
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-
SHOW
OGA Small Molecule 5PNU
-
-
SHOW
OGA Small Molecule 5PI0
-
-
SHOW
OGA Small Molecule 5PLQ
-
-
SHOW
OGA Small Molecule 5PM0
-
-
SHOW
OGA Small Molecule 5PL3
-
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SHOW
OGA Small Molecule 5PH1
-
-
SHOW
OGA Small Molecule 5PIS
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SHOW
OGA Small Molecule 5PNL
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-
SHOW
OGA Small Molecule 5PN4
-
-
SHOW
OGA Small Molecule 5PIH
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-
SHOW
OGA Small Molecule 5PNW
-
-
SHOW
OGA Small Molecule 5PJP
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-
SHOW
OGA Small Molecule 5PNA
-
-
SHOW
OGA Small Molecule 5PKH
-
-
SHOW
OGA Small Molecule 5PK9
-
-
SHOW
CQT Small Molecule 6F5S
-
-
SHOW
OGA Small Molecule 5PL5
-
-
SHOW
CTK Small Molecule 6F5Q
-
-
SHOW
BX5 Small Molecule 6ETW
-
-
SHOW
OGA Small Molecule 5PIJ
-
-
SHOW
OGA Small Molecule 5PIP
-
-
SHOW
OGA Small Molecule 5PN3
-
-
SHOW
OGA Small Molecule 5PL6
-
-
SHOW
OGA Small Molecule 5PNV
-
-
SHOW
OGA Small Molecule 5PHA
-
-
SHOW
OGA Small Molecule 5PK4
-
-
SHOW
OGA Small Molecule 5PLO
-
-
SHOW
FHQ Small Molecule 6H0Z
-
-
SHOW
OGA Small Molecule 5PKL
-
-
SHOW
OGA Small Molecule 5PLP
-
-
SHOW
OGA Small Molecule 5PHQ
-
-
SHOW
OGA Small Molecule 5PL4
-
-
SHOW
5V3 Small Molecule 5F5C
-
-
SHOW
OGA Small Molecule 5PID
-
-
SHOW
OGA Small Molecule 5PJN
-
-
SHOW
OGA Small Molecule 5PK0
-
-
SHOW
OGA Small Molecule 5PM1
-
-
SHOW
OGA Small Molecule 5PMX
-
-
SHOW
OGA Small Molecule 5PM6
-
-
SHOW
OGA Small Molecule 5PIC
-
-
SHOW
OGA Small Molecule 5PLL
-
-
SHOW
OGA Small Molecule 5PIQ
-
-
SHOW
OGA Small Molecule 5PN5
-
-
SHOW
AKG Small Molecule 4HON
-
-
SHOW
OGA Small Molecule 5PHB
-
-
SHOW
OGA Small Molecule 5PJV
-
-
SHOW
OGA Small Molecule 5PHW
-
-
SHOW
OGA Small Molecule 5PKO
-
-
SHOW
OGA Small Molecule 5PNQ
-
-
SHOW
OGA Small Molecule 5PNR
-
-
SHOW
OGA Small Molecule 5PMF
-
-
SHOW
OGA Small Molecule 5PJA
-
-
SHOW
OGA Small Molecule 5PLG
-
-
SHOW
OGA Small Molecule 5PIT
-
-
SHOW
OGA Small Molecule 5PJZ
-
-
SHOW
OGA Small Molecule 5PL8
-
-
SHOW
I1L Small Molecule 6ETS
-
-
SHOW
OGA Small Molecule 5PMB
-
-
SHOW
OGA Small Molecule 5PHJ
-
-
SHOW
OGA Small Molecule 5PKM
-
-
SHOW
OGA Small Molecule 5PK7
-
-
SHOW
FJ8 Small Molecule 6H10
-
-
SHOW
OGA Small Molecule 5PK1
-
-
SHOW
OGA Small Molecule 5PJ6
-
-
SHOW
OGA Small Molecule 5PNE
-
-
SHOW
OGA Small Molecule 3DXU
-
-
SHOW
OGA Small Molecule 5PH0
-
-
SHOW
OGA Small Molecule 5PK3
-
-
SHOW
OGA Small Molecule 5PLM
-
-
SHOW
OGA Small Molecule 5PJW
-
-
SHOW
OGA Small Molecule 5PKX
-
-
SHOW
OGA Small Molecule 5PJG
-
-
SHOW
OGA Small Molecule 5PME
-
-
SHOW
OGA Small Molecule 5PJ5
-
-
SHOW
OGA Small Molecule 5PJC
-
-
SHOW
BWK Small Molecule 6ETE
-
-
SHOW
OGA Small Molecule 5PJL
-
-
SHOW
OGA Small Molecule 5PMV
-
-
SHOW
OGA Small Molecule 5PI9
-
-
SHOW
OGA Small Molecule 5PH8
-
-
SHOW
OGA Small Molecule 5PKN
-
-
SHOW
OGA Small Molecule 5PHT
-
-
SHOW
OGA Small Molecule 5PHR
-
-
SHOW
OGA Small Molecule 5PHP
-
-
SHOW
OGA Small Molecule 5PJB
-
-
SHOW
OGA Small Molecule 5PJ0
-
-
SHOW
OGA Small Molecule 5PLS
-
-
SHOW
OGA Small Molecule 5PN7
-
-
SHOW
OGA Small Molecule 5PHZ
-
-
SHOW
OGA Small Molecule 5PLV
-
-
SHOW
OGA Small Molecule 5PNI
-
-
SHOW
OGA Small Molecule 5PIY
-
-
SHOW
OGA Small Molecule 5PL9
-
-
SHOW
OGA Small Molecule 5PHC
-
-
SHOW
BXE Small Molecule 6ETV
-
-
SHOW
OGA Small Molecule 5PKT
-
-
SHOW
OGA Small Molecule 5PIF
-
-
SHOW
OGA Small Molecule 5PLJ
-
-
SHOW
OGA Small Molecule 5PJY
-
-
SHOW
OGA Small Molecule 5PN0
-
-
SHOW
OGA Small Molecule 5PKF
-
-
SHOW
OGA Small Molecule 5PK2
-
-
SHOW
OGA Small Molecule 5PKC
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SHOW
OGA Small Molecule 5PNH
-
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SHOW
OGA Small Molecule 5PL2
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SHOW
OGA Small Molecule 5PHU
-
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SHOW