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Protein Download |
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| Protein Name | Polycomb protein EED | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 34 | |||||
| Organism | Homo sapiens | |||||
| Uniprot ID/ACC | O75530 (EED_HUMAN) | |||||
| Protein Sequence | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR | |||||
| Protein Class | TRANSCRIPTION REGULATOR | |||||
| Synonym(s) |
|
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| Gene Symbol | EED | |||||
| Gene ID | 8726 | |||||
| Pfam ID | PF00400 | |||||
| Interpro ID | IPR037352, IPR015943, IPR001680, IPR019775, IPR017986, IPR036322 |
Bound Ligands |
HET ID | Ligand Type | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| LQF | Small Molecule | 5H19 | IC50 : 320.0 nM | Binding MOAD |  |
SHOW |
| 73K | Small Molecule | 5GSA | Kd : 82.5 nM | Binding MOAD |  |
SHOW |
| 73K | Small Molecule | 5WUK | Kd : 14.0 nM | Binding MOAD | |
SHOW |
| LQA | Small Molecule | 5H13 | IC50 : 11580.0 nM | Binding MOAD |  |
SHOW |
| LQB | Small Molecule | 5H14 | IC50 : 8760.0 nM | Binding MOAD |  |
SHOW |
| 7VY | Small Molecule | 5U5K | IC50 : 95000.0 nM | Binding MOAD |  |
SHOW |
| 7W7 | Small Molecule | 5U5T | IC50 : 3900.0 nM | Binding MOAD |  |
SHOW |
| 7XG | Small Molecule | 5U6D | Ki : 2.6 nM | Binding MOAD |  |
SHOW |
| 82D | Small Molecule | 5U8A | Ki : 13.0 nM | Binding MOAD |  |
SHOW |
| 82G | Small Molecule | 5U8F | Ki : 11.0 nM | Binding MOAD |  |
SHOW |
| LQD | Small Molecule | 5H15 | IC50 : 1570.0 nM | Binding MOAD |  |
SHOW |
| LQE | Small Molecule | 5H17 | IC50 : 890.0 nM | Binding MOAD |  |
SHOW |
| M3L | H1K26me3 | 3IIY |
- |
- |
 |
SHOW |
| LQG | Small Molecule | 5H24 |
- |
- |
 |
SHOW |
| M3L | H3K27me3 | 5HYN |
- |
- |
|
SHOW |
| M3L | Peptidomimetic Ligands | 5TTW |
- |
- |
|
SHOW |
| M3L | H4K20me3 | 3JPX |
- |
- |
|
SHOW |
| Q3D | Small Molecule | 6W7F |
- |
- |
 |
SHOW |
| M3L | H3K27me3 | 5LS6 |
- |
- |
|
SHOW |
| M3L | H4K20me3 | 3IJ1 |
- |
- |
|
SHOW |
| LQH | Small Molecule | 5H25 |
- |
- |
 |
SHOW |
| M3L | H3K9me3 | 3K27 |
- |
- |
|
SHOW |
| 6PU | Small Molecule | 5K0M |
- |
- |
 |
SHOW |
| L9K | Small Molecule | 6SFB |
- |
- |
 |
SHOW |
| NDS | Small Molecule | 3IJC |
- |
- |
 |
SHOW |
| M3L | H3K27me3 | 3JZG |
- |
- |
|
SHOW |
| Q3A | Small Molecule | 6W7G |
- |
- |
 |
SHOW |
| M3L | JARID2 me3 | 6C23 |
- |
- |
|
SHOW |
| M3L | H3K4me3 | 3K26 |
- |
- |
|
SHOW |
| M3L | H3K79me3 | 3JZH |
- |
- |
|
SHOW |
| M3L | H3K27me3 | 6C24 |
- |
- |
|
SHOW |
| M3L | H3K9me3 | 3IJ0 |
- |
- |
|
SHOW |
| M3L | Jarid2-K116me3 | 4X3E |
- |
- |
|
SHOW |
| M3L | H3K27me3 | 3IIW |
- |
- |
|
SHOW |