Protein

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Protein Name Lysine-specific demethylase 4A
#PDB ID 16
Organism Homo sapiens
Uniprot ID/ACC O75164 (KDM4A_HUMAN)
Protein Sequence MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
Protein Class TRANSCRIPTION REGULATOR
Synonym(s)
  •   lysine-specific demethylase 4A
  • [histone H3]-trimethyl-L-lysine(36) demethylase 4A
  • [histone H3]-trimethyl-L-lysine(9) demethylase 4A
  • jmjC domain-containing histone demethylation protein 3A
  • jumonji C domain-containing histone demethylase 3A
  • jumonji domain containing 2
  • jumonji domain containing 2A
  • jumonji domain-containing protein 2A
  • lysine (K)-specific demethylase 4A
  • tudor domain containing 14A
  • JHDM3A
  • JMJD2
  • JMJD2A
  • TDRD14A
show 13 synonym(s)
Gene Symbol KDM4A
Gene ID 9682
Pfam ID PF02373, PF02375, PF18104
Interpro ID IPR034732, IPR003347, IPR003349, IPR040477, IPR002999, IPR011011, IPR001965, IPR013083
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
FQE Small Molecule 6H4S Ki : 2.0 nM Binding MOAD SHOW
FQB Small Molecule 6H4R Ki : 0.004 nM Binding MOAD SHOW
FOW Small Molecule 6H4T Ki : 4.0 nM Binding MOAD SHOW
FQN Small Molecule 6H4V IC50 : 613.0 nM Binding MOAD SHOW
FO8 Small Molecule 6H4Y IC50 : 77.0 nM Binding MOAD SHOW
FNQ Small Molecule 6H4X IC50 : 131.0 nM Binding MOAD SHOW
FQH Small Molecule 6H4O IC50 : 128.0 nM Binding MOAD SHOW
FQ5 Small Molecule 6H4P Ki : 3.0 nM Binding MOAD SHOW
92Y Small Molecule 5VAR Kd : 81700.0 nM Binding MOAD SHOW
OGA Small Molecule 5LY2
-
-
SHOW
M3L H3K23me3 5D6Y
-
-
SHOW
M3L H4K20me3 2QQS
-
-
SHOW
FO2 Small Molecule 6H4U
-
-
SHOW
QC1 Small Molecule 6CG1
-
-
SHOW
M3L H3K4me3 2GFA
-
-
SHOW
FQQ Small Molecule 6H4W
-
-
SHOW