Protein

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Protein Name Lysine-specific demethylase 5B
#PDB ID 10
Organism Homo sapiens
Uniprot ID/ACC Q9UGL1 (KDM5B_HUMAN)
Protein Sequence MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEFDVELPQLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAGGRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTENSPYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWDNRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQQTDRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVKDAPSRK
Protein Class TRANSCRIPTION REGULATOR
Synonym(s)
  •   lysine-specific demethylase 5B
  • [histone H3]-trimethyl-L-lysine(4) demethylase 5B
  • cancer/testis antigen 31
  • histone demethylase JARID1B
  • jumonji, AT rich interactive domain 1B
  • jumonji/ARID domain-containing protein 1B
  • lysine (K)-specific demethylase 5B
  • protein phosphatase 1, regulatory subunit 98
  • putative DNA/chromatin binding motif
  • retinoblastoma-binding protein 2 homolog 1
  • retinoblastoma-binding protein 2, homolog 1A
  • CT31
  • JARID1B
  • MRT65
  • PLU-1
  • PLU1
  • PPP1R98
  • PUT1
  • RBBP2H1A
  • RBP2-H1
show 19 synonym(s)
Gene Symbol KDM5B
Gene ID 10765
Pfam ID PF01388, PF02373, PF02375, PF00628, PF08429, PF02928
Interpro ID IPR001606, IPR036431, IPR003347, IPR003349, IPR013637, IPR019786, IPR004198, IPR011011, IPR001965, IPR019787, IPR013083
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
FQ5 Small Molecule 6H4Z Ki : 2.0 nM Binding MOAD SHOW
FQN Small Molecule 6H52 IC50 : 68.0 nM Binding MOAD SHOW
0TI Small Molecule 5FZH
-
-
SHOW
B7Q Small Molecule 6EJ1
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-
SHOW
B6W Small Molecule 6EIY
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-
SHOW
B6T Small Molecule 6EIU
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-
SHOW
79H Small Molecule 5LWB
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-
SHOW
BY4 Small Molecule 5FYU
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-
SHOW
B7K Small Molecule 6EJ0
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-
SHOW
JX8 Small Molecule 6RBI
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-
SHOW