Ligand

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Ligand Name:   N-TRIMETHYLLYSINE
HET ID:   M3L PubChem:   440121, 6992003
DrugBank:   DB03977 ChEMBL:   CHEMBL1234168
Canonical SMILES:   OC(=O)[C@H](CCCC[N+](C)(C)C)N
Standard InChI:   InChI=1S/C9H20N2O2/c1-11(2,3)7-5-4-6-8(10)9(12)13/h8H,4-7,10H2,1-3H3/p+1/t8-/m0/s1
Molecular Formula:   C9H21N2O2+ Mol. Weight:   189.27524 Heavy Atoms:   13
Charge:   1 Is Chiral:   True logP:   0.9751
HBD:   2 HBA:   3 TPSA:   63.32
#Bonds:   13 #Rotatable Bonds:   6 Shape Complexity:   0.8888889
Stereocomplexity:   0.11111111
Bound Proteins
Protein Name Uniprot ID/ACC Organism PDB ID Binding Affinity Binding Database Complex Card
a plant-specific histone reader SHORT LIFE (SHL) B9H0V2 (B9H0V2_POPTR) Populus trichocarpa 5ZNP
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SHOW
PHD finger protein ALFIN-LIKE 1 Q9M2B4 (ALFL3_ARATH) Arabidopsis thaliana 5YC4
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SHOW
Chromobox protein homolog 7 O95931 (CBX7_HUMAN) Homo sapiens 2L12
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SHOW
WD_REPEATS_REGION domain-containing protein G0S8H7 (G0S8H7_CHATD) Chaetomium thermophilum 5WFC
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SHOW
Nucleosome-remodeling factor subunit BPTF Q12830 (BPTF_HUMAN) Homo sapiens 2FUU
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SHOW
Polycomb group protein Pc P26017 (PC_DROME) Drosophila melanogaster 1PDQ
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SHOW
Lysine-specific demethylase 4A O75164 (KDM4A_HUMAN) Homo sapiens 5D6Y
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SHOW
Spindlin-2B Q9BPZ2 (SPI2B_HUMAN) Homo sapiens 5LUG
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SHOW
a plant-specific histone reader SHORT LIFE (SHL) B9H0V2 (B9H0V2_POPTR) Populus trichocarpa 5ZNR
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SHOW
Spindlin-4 Q56A73 (SPIN4_HUMAN) Homo sapiens 4UY4
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 7BQZ
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SHOW
Lysine-specific demethylase 7 homolog Q9GYI0 (KDM7_CAEEL) Caenorhabditis elegans 3N9Q
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3IIY
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SHOW
Chromobox protein homolog 7 O95931 (CBX7_HUMAN) Homo sapiens 2L1B
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SHOW
E3 ubiquitin-protein ligase TRIM33 Q9UPN9 (TRI33_HUMAN) Homo sapiens 3U5O
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SHOW
Lysine-specific demethylase 4A O75164 (KDM4A_HUMAN) Homo sapiens 2QQS
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SHOW
Protein YNG1 Q08465 (YNG1_YEAST) Saccharomyces cerevisiae 2JMJ
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SHOW
V(D)J recombination-activating protein 2 P21784 (RAG2_MOUSE) Mus musculus 2V85
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SHOW
MORC family CW-type zinc finger protein 3 F7BJB9 (MORC3_MOUSE) Mus musculus 5IX1
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SHOW
SAGA-associated factor 29 P25554 (SGF29_YEAST) Saccharomyces cerevisiae 3MP1
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SHOW
Chromodomain-helicase-DNA-binding protein 1 O14646 (CHD1_HUMAN) Homo sapiens 2B2W
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SHOW
Chromodomain Y-like protein 2 Q8N8U2 (CDYL2_HUMAN) Homo sapiens 6V2H
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SHOW
PHD finger protein 13 Q86YI8 (PHF13_HUMAN) Homo sapiens 3O7A
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SHOW
Zinc finger CW-type PWWP domain protein 1 Q504Y3 (ZCPW2_HUMAN) Homo sapiens 4Z0R
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SHOW
Lysine-specific demethylase 7 homolog Q9GYI0 (KDM7_CAEEL) Caenorhabditis elegans 3N9L
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SHOW
SAGA-associated factor 29 Q96ES7 (SGF29_HUMAN) Homo sapiens 3ME9
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SHOW
Histone-lysine N-methyltransferase 2A Q03164 (KMT2A_HUMAN) Homo sapiens 3LQJ
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SHOW
Chromobox protein homolog 5 P45973 (CBX5_HUMAN) Homo sapiens 3FDT
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SHOW
COMPASS component SPP1 Q03012 (SPP1_YEAST) Saccharomyces cerevisiae 6J2P
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SHOW
E3 ubiquitin-protein ligase UHRF1 Q96T88 (UHRF1_HUMAN) Homo sapiens 5YY9
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SHOW
Hepatoma-derived growth factor-related protein 3 Q9Y3E1 (HDGR3_HUMAN) Homo sapiens 6IIS
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SHOW
Transcription initiation factor TFIID subunit 3 Q5HZG4 (TAF3_MOUSE) Mus musculus 2K17
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 5HYN
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 5TTW
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SHOW
WD_REPEATS_REGION domain-containing protein G0S8H7 (G0S8H7_CHATD) Chaetomium thermophilum 5M5G
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3JPX
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SHOW
SAGA-associated factor 29 Q96ES7 (SGF29_HUMAN) Homo sapiens 3MEA
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SHOW
M-phase phosphoprotein 8 Q99549 (MPP8_HUMAN) Homo sapiens 3R93
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SHOW
AT-rich interactive domain-containing protein 5 Q6NQ79 (ARID4_ARATH) Arabidopsis thaliana 6LQE
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SHOW
Chromodomain-helicase-DNA-binding protein 1 O14646 (CHD1_HUMAN) Homo sapiens 2B2T
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 7BQZ
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SHOW
Chromobox protein homolog 3 Q13185 (CBX3_HUMAN) Homo sapiens 2L11
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SHOW
WD_REPEATS_REGION domain-containing protein G0S8H7 (G0S8H7_CHATD) Chaetomium thermophilum 5KKL
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SHOW
V(D)J recombination-activating protein 2 P21784 (RAG2_MOUSE) Mus musculus 2V86
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SHOW
Hepatoma-derived growth factor-related protein 2 Q7Z4V5 (HDGR2_HUMAN) Homo sapiens 3QBY
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SHOW
E3 ubiquitin-protein ligase UHRF1 Q96T88 (UHRF1_HUMAN) Homo sapiens 3DB3
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SHOW
Peregrin P55201 (BRPF1_HUMAN) Homo sapiens 2X4X
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 5LS6
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3IJ1
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SHOW
Chromobox protein homolog 3 Q13185 (CBX3_HUMAN) Homo sapiens 3DM1
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3K27
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SHOW
Chromobox protein homolog 6 O95503 (CBX6_HUMAN) Homo sapiens 3GV6
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SHOW
Heterochromatin protein 1 P05205 (HP1_DROME) Drosophila melanogaster 6AT0
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SHOW
E3 ubiquitin-protein ligase UHRF1 Q96T88 (UHRF1_HUMAN) Homo sapiens 3ASK
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SHOW
Protein partner of snf, isoform A Q9VG78 (Q9VG78_DROME) Drosophila melanogaster 5WLE
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SHOW
Pygopus homolog 1 Q9D0P5 (PYGO1_MOUSE) Mus musculus 2YYR
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SHOW
Inhibitor of growth protein 4 Q9UNL4 (ING4_HUMAN) Homo sapiens 2PNX
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SHOW
Lysine-specific demethylase 7 homolog Q9GYI0 (KDM7_CAEEL) Caenorhabditis elegans 3N9P
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SHOW
Zinc finger MYND domain-containing protein 11 Q8R5C8 (ZMY11_MOUSE) Mus musculus 4N4I
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 4MZH
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SHOW
Transcription initiation factor TFIID subunit 3 Q5VWG9 (TAF3_HUMAN) Homo sapiens 5WXH
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SHOW
Death-inducer obliterator 1 Q9BTC0 (DIDO1_HUMAN) Homo sapiens 4L7X
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SHOW
304M3-B Fab None () Homo sapiens 4YHY
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SHOW
E3 ubiquitin-protein ligase UHRF1 Q96T88 (UHRF1_HUMAN) Homo sapiens 4GY5
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SHOW
Histone-lysine N-methyltransferase SETDB1 Q15047 (SETB1_HUMAN) Homo sapiens 6BHE
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 4MZF
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SHOW
Protein MRG2 Q4V3E2 (MRG2_ARATH) Arabidopsis thaliana 4PLL
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 5Y5W
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SHOW
Protein MRG2 Q4V3E2 (MRG2_ARATH) Arabidopsis thaliana 4PLI
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SHOW
V(D)J recombination-activating protein 2 P21784 (RAG2_MOUSE) Mus musculus 2V83
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3JZG
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SHOW
Chromodomain Y-like protein 2 Q8N8U2 (CDYL2_HUMAN) Homo sapiens 6V3N
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SHOW
304M3-B Fab None () Homo sapiens 4YHP
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 7BU9
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SHOW
Chromobox protein homolog 7 Q8VDS3 (CBX7_MOUSE) Mus musculus 4X3S
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SHOW
SAGA-associated factor 29 Q96ES7 (SGF29_HUMAN) Homo sapiens 3MEU
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SHOW
V(D)J recombination-activating protein 2 P21784 (RAG2_MOUSE) Mus musculus 2V87
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SHOW
MORC family CW-type zinc finger protein 3 Q14149 (MORC3_HUMAN) Homo sapiens 4QQ4
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SHOW
Chromo domain-containing protein 1 Q10103 (CHP1_SCHPO) Schizosaccharomyces pombe 2RSN
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 6C23
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SHOW
PHD finger protein 1 O43189 (PHF1_HUMAN) Homo sapiens 4HCZ
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SHOW
Chromobox protein homolog 5 Q61686 (CBX5_MOUSE) Mus musculus 2RVN
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SHOW
Chromobox protein homolog 6 O95503 (CBX6_HUMAN) Homo sapiens 3I90
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SHOW
Protein SAWADEE HOMEODOMAIN HOMOLOG 1 Q9XI47 (SHH1_ARATH) Arabidopsis thaliana 4IUR
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SHOW
Zinc finger CW-type PWWP domain protein 1 Q9H0M4 (ZCPW1_HUMAN) Homo sapiens 2RR4
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SHOW
DNA (cytosine-5)-methyltransferase 3B Q9UBC3 (DNM3B_HUMAN) Homo sapiens 5CIU
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SHOW
WD_REPEATS_REGION domain-containing protein G0S8H7 (G0S8H7_CHATD) Chaetomium thermophilum 5KJH
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SHOW
M-phase phosphoprotein 8 Q99549 (MPP8_HUMAN) Homo sapiens 3QO2
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SHOW
AT-rich interactive domain-containing protein 5 Q6NQ79 (ARID4_ARATH) Arabidopsis thaliana 6LQF
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SHOW
Chromobox protein homolog 8 Q9HC52 (CBX8_HUMAN) Homo sapiens 3I91
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SHOW
Zinc finger MYND domain-containing protein 11 Q8R5C8 (ZMY11_MOUSE) Mus musculus 4N4H
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SHOW
Metal-response element-binding transcription factor 2 Q9Y483 (MTF2_HUMAN) Homo sapiens 5XFR
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SHOW
Lysine-specific demethylase 5A P29375 (KDM5A_HUMAN) Homo sapiens 2KGI
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SHOW
Lysine-specific demethylase 7 homolog Q9GYI0 (KDM7_CAEEL) Caenorhabditis elegans 3N9N
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SHOW
Heterochromatin protein 1 P05205 (HP1_DROME) Drosophila melanogaster 6MHA
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SHOW
Heterochromatin protein 1 P05205 (HP1_DROME) Drosophila melanogaster 1KNE
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SHOW
Protein MRG2 Q4V3E2 (MRG2_ARATH) Arabidopsis thaliana 4PL6
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SHOW
Inhibitor of growth protein 4 Q9UNL4 (ING4_HUMAN) Homo sapiens 2VNF
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SHOW
Testis-specific chromodomain protein Y 1 Q9Y6F8 (CDY1_HUMAN) Homo sapiens 6V41
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SHOW
Chromodomain-helicase-DNA-binding protein 1 O14646 (CHD1_HUMAN) Homo sapiens 4NW2
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SHOW
Polycomb group protein Pc P26017 (PC_DROME) Drosophila melanogaster 1PFB
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SHOW
PHD finger protein 19 Q5T6S3 (PHF19_HUMAN) Homo sapiens 6WAV
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SHOW
PHD finger protein 1 O43189 (PHF1_HUMAN) Homo sapiens 2M0O
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SHOW
RE36324p Q7JXA8 (Q7JXA8_DROME) Drosophila melanogaster 4QUF
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SHOW
MORC family CW-type zinc finger protein 3 Q14149 (MORC3_HUMAN) Homo sapiens 5SVX
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SHOW
PHD finger protein 8 Q9UPP1 (PHF8_HUMAN) Homo sapiens 3KV4
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SHOW
Hepatoma-derived growth factor-related protein 2 Q7Z4V5 (HDGR2_HUMAN) Homo sapiens 3QJ6
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 4MZG
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SHOW
Lysine-specific demethylase 5A P29375 (KDM5A_HUMAN) Homo sapiens 3GL6
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SHOW
Chromatin remodeling protein EBS F4JL28 (EBS_ARATH) Arabidopsis thaliana 5Z8L
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SHOW
BAH and coiled-coil domain-containing protein 1 Q3UHR0 (BAHC1_MOUSE) Mus musculus 6VIL
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SHOW
Peregrin P55201 (BRPF1_HUMAN) Homo sapiens 2X4Y
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SHOW
PHD finger protein 19 Q5T6S3 (PHF19_HUMAN) Homo sapiens 6WAU
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3K26
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3JZH
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 6C24
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SHOW
PHD finger protein 1 O43189 (PHF1_HUMAN) Homo sapiens 6WAT
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SHOW
RE36324p Q7JXA8 (Q7JXA8_DROME) Drosophila melanogaster 4U68
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SHOW
PHD finger protein ALFIN-LIKE 1 Q9FFF5 (ALFL1_ARATH) Arabidopsis thaliana 5Y20
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SHOW
Lysine-specific demethylase 7 homolog Q9GYI0 (KDM7_CAEEL) Caenorhabditis elegans 3N9O
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SHOW
PHD finger protein 19 Q5T6S3 (PHF19_HUMAN) Homo sapiens 4BD3
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SHOW
Lysine-specific demethylase 4A O75164 (KDM4A_HUMAN) Homo sapiens 2GFA
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SHOW
Transcription initiation factor TFIID subunit 3 Q5VWG9 (TAF3_HUMAN) Homo sapiens 5XMY
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3IJ0
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SHOW
PHD finger protein 1 Q9Z1B8 (PHF1_MOUSE) Mus musculus 5XFQ
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SHOW
304M3-B Fab None () Homo sapiens 4YHZ
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SHOW
Chromodomain-helicase-DNA-binding protein 1 O14646 (CHD1_HUMAN) Homo sapiens 2B2U
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SHOW
Chromobox protein homolog 1 P83916 (CBX1_HUMAN) Homo sapiens 6D07
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SHOW
Inhibitor of growth protein 5 Q8WYH8 (ING5_HUMAN) Homo sapiens 3C6W
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SHOW
Zinc finger CW-type PWWP domain protein 1 Q504Y3 (ZCPW2_HUMAN) Homo sapiens 4O62
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 4X3E
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SHOW
PHD finger protein 2 O75151 (PHF2_HUMAN) Homo sapiens 3KQI
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SHOW
Chromo domain-containing protein 1 Q10103 (CHP1_SCHPO) Schizosaccharomyces pombe 3G7L
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SHOW
Polycomb protein EED O75530 (EED_HUMAN) Homo sapiens 3IIW
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SHOW
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 (RBCMT_PEA) Pisum sativum 2H23
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SHOW
Chromobox protein homolog 7 Q8VDS3 (CBX7_MOUSE) Mus musculus 4X3K
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SHOW
Peregrin P55201 (BRPF1_HUMAN) Homo sapiens 2X4W
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SHOW
Peregrin P55201 (BRPF1_HUMAN) Homo sapiens 3MO8
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SHOW
V(D)J recombination-activating protein 2 P21784 (RAG2_MOUSE) Mus musculus 2V89
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SHOW
SAGA-associated factor 29 Q96ES7 (SGF29_HUMAN) Homo sapiens 3MEV
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SHOW
Nucleosome-remodeling factor subunit BPTF Q12830 (BPTF_HUMAN) Homo sapiens 2F6J
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SHOW
Chromobox protein homolog 2 Q14781 (CBX2_HUMAN) Homo sapiens 3H91
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SHOW
Chromobox protein homolog 7 O95931 (CBX7_HUMAN) Homo sapiens 4MN3
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SHOW
Histone-lysine N-methyltransferase SETDB1 Q15047 (SETB1_HUMAN) Homo sapiens 6BHI
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SHOW
Inhibitor of growth protein 1 Q9UK53 (ING1_HUMAN) Homo sapiens 2QIC
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SHOW
Inhibitor of growth protein 2 Q9ESK4 (ING2_MOUSE) Mus musculus 2G6Q
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SHOW
Spindlin-1 Q9Y657 (SPIN1_HUMAN) Homo sapiens 4H75
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SHOW
Heterochromatin protein 1 P05205 (HP1_DROME) Drosophila melanogaster 6ASZ
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SHOW