Protein |
||||||
| Protein Name | Carbapenem-hydrolyzing beta-lactamase KPC | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 22 | |||||
| Organism | Klebsiella pneumoniae | |||||
| Uniprot ID/ACC | Q9F663 (BLKPC_KLEPN) | |||||
| Synonym(s) |
|
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| Gene Symbol | bla | |||||
| Gene ID | 56982589 | |||||
| Sequence | MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ | |||||
| Protein Class | HYDROLASE | |||||
| Function | Hydrolyzes carbapenems, penicillins, cephalosporins and monobactams with varying efficiency. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB618 | C8V | 6B1J | Kd : 43 nM | PDBBind |  |
SHOW |
| COVPDB619 | C8Y | 6B1H | Kd : 1.9 nM | PDBBind |  |
SHOW |
| COVPDB619 | C8Y | 6B1F | Kd : 1.9 nM | PDBBind | |
SHOW |
| COVPDB620 | C9D | 6B1X | Kd : 40 nM | PDBBind |  |
SHOW |
| COVPDB1511 | ZXM | 5EEC | IC50 : 80 nM | PDBBind |  |
SHOW |
| COVPDB989 | JJT | 6QW9 |
- |
- |
 |
SHOW |
| COVPDB1151 | NPB | 3RXX |
- |
- |
 |
SHOW |
| COVPDB989 | JJT | 6QWA |
- |
- |
|
SHOW |
| COVPDB1324 | SR3 | 3RXW |
- |
- |
 |
SHOW |
| COVPDB1034 | KJK | 6TD1 |
- |
- |
 |
SHOW |
| COVPDB1284 | RM9 | 6V1J |
- |
- |
 |
SHOW |
| COVPDB224 | 4D6 | 6V7I |
- |
- |
 |
SHOW |
| COVPDB989 | MK7 | 6QW9 |
- |
- |
|
SHOW |
| COVPDB593 | BX6 | 6JN3 |
- |
- |
 |
SHOW |
| COVPDB1157 | NXL | 4ZBE |
- |
- |
 |
SHOW |
| COVPDB989 | MK7 | 6QWB |
- |
- |
|
SHOW |
| COVPDB989 | MK7 | 6QWA |
- |
- |
|
SHOW |
| COVPDB989 | JJT | 6QWB |
- |
- |
|
SHOW |
| COVPDB989 | MK7 | 6QWC |
- |
- |
|
SHOW |
| COVPDB562 | BX9 | 6JN4 |
- |
- |
 |
SHOW |
| COVPDB224 | 4D6 | 6TD0 |
- |
- |
|
SHOW |
| COVPDB562 | BHU | 6J8Q |
- |
- |
|
SHOW |