21 Mechanism(s)
Mechanism Name
#Ligands
#Proteins
#Warheads
#Residues
#Protein-Ligand Complex(es)
1 Aziridine Opening 15 14 1 3 18
2 Beta-Lactam Addition 101 78 1 3 280
3 Borylation 132 56 3 4 200
4 Composite Reaction 31 30 14 8 42
5 Cyclohemiaminoacetalization 11 7 4 2 12
6 Disulfide Formation 51 35 3 1 62
7 Epoxide Opening 69 53 1 7 116
8 Hemiaminalization 10 10 2 2 13
9 Hemi(thio)acetalization 180 82 4 5 243
10 Imidazolidinone Opening 11 25 1 1 53
11 Imine Condensation 75 51 4 3 123
12 Lactone Addition 23 17 4 4 29
13 Michael Addition 289 116 11 5 363
14 Nucleophilic Acyl Substitution 92 96 17 8 140
15 Nucleophilic Addition to a Double Bond 30 25 13 4 44
16 Nucleophilic Addition to a Triple Bond 94 26 4 4 100
17 Nucleophilic Aliphatic Subsititution 167 112 18 10 226
18 Nucleophilic Aromatic Substitution 29 25 7 5 43
19 Phosphorylation 63 65 6 6 116
20 Ring Opening 32 24 13 6 41
21 Sulfonylation 21 21 2 3 30