Covpdb











Protein
Protein Name Major histocompatibility complex class I-related gene protein
#PDB ID 31
Organism Homo sapiens (Human)
Uniprot ID/ACC Q95460 (HMR1_HUMAN)
Synonym(s)
  •   MHC class I-like antigen MR-1
  • MHC class-I related-gene protein
  • major histocompatibility complex
  • class I-like sequence
  • HLALS
show 4 synonym(s)
Gene Symbol MR1
Gene ID 3140
Sequence MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR
Protein Class CELL CYCLE
Function Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells (PubMed:23051753, PubMed:26795251, PubMed:12794138, PubMed:19416870, PubMed:22692454, PubMed:23846752). In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:26795251, PubMed:24695216, PubMed:20581831). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (PubMed:24695216). May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin (PubMed:27527800, PubMed:31113973). Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (PubMed:24695216, PubMed:27527800, PubMed:23846752). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome (PubMed:31959982). May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types (PubMed:31959982).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB171 30W 4PJI Kd : >200000 nM PDBBind SHOW
COVPDB387 7WQ 5U2V
-
-
SHOW
COVPDB171 30W 4PJX
-
-
SHOW
COVPDB1202 OYD 6PUD
-
-
SHOW
COVPDB1253 Q81 6PUL
-
-
SHOW
COVPDB145 2LJ 4NQC
-
-
SHOW
COVPDB1251 Q7P 6PUI
-
-
SHOW
COVPDB1250 Q7J 6PUE
-
-
SHOW
COVPDB1254 Q84 6PUM
-
-
SHOW
COVPDB144 2L4 4NQE
-
-
SHOW
COVPDB1252 Q7S 6PUJ
-
-
SHOW
COVPDB145 2LJ 6PUF
-
-
SHOW
COVPDB385 7WO 5U16
-
-
SHOW
COVPDB386 7WP 5U17
-
-
SHOW
COVPDB145 2LJ 5D5M
-
-
SHOW
COVPDB171 30W 4PJH
-
-
SHOW
COVPDB171 30W 4PJF
-
-
SHOW
COVPDB171 30W 4PJG
-
-
SHOW
COVPDB1205 OZD 6PUG
-
-
SHOW
COVPDB145 2LJ 4PJ7
-
-
SHOW
COVPDB145 Q87 6PUC
-
-
SHOW
COVPDB145 2LJ 4PJC
-
-
SHOW
COVPDB308 6FP 4L4T
-
-
SHOW
COVPDB171 30W 5D7I
-
-
SHOW
COVPDB1204 OYV 6PUK
-
-
SHOW
COVPDB389 7ZS 5U6Q
-
-
SHOW
COVPDB171 30W 4PJ5
-
-
SHOW
COVPDB1203 OYG 6PUH
-
-
SHOW
COVPDB171 TKG 6W9U
-
-
SHOW
COVPDB171 30W 4PJE
-
-
SHOW
COVPDB145 2LJ 5D7J
-
-
SHOW