Protein
Protein Name Delta-aminolevulinic acid dehydratase
#PDB ID 8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Uniprot ID/ACC P05373 (HEM2_YEAST)
Synonym(s)
  •   porphobilinogen synthase HEM2
  • YGL040C
  • OLE4
  • SLU1
show 3 synonym(s)
Gene Symbol HEM2
Gene ID 852842
Sequence MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDNPDDFTEIDSLPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDPVGTAADDPAGPVIQGIKFIREYFPELYIICDVCLCEYTSHGHCGVLYDDGTINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAHKTFVLSYAAKFSGNLYGPFRDAACSAPSNGDRKCYQLPPAGRGLARRALERDMSEGADGIIVKPSTFYLDIMRDASEICKDLPICAYHVSGEYAMLHAAAEKGVVDLKTIAFESHQGFLRAGARLIITYLAPEFLDWLDEEN
Protein Class LYASE
Function Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1308 SHF 1YLV Ki : 2000000 nM PDBBind SHOW
COVPDB1310 SHO 1W31 Ki : 250000 nM PDBBind SHOW
COVPDB1310 SHO 1W31 Ki : 250000 nM Binding MOAD SHOW
COVPDB239 4OX 1GJP
-
-
SHOW
COVPDB1311 SHU 1H7R
-
-
SHOW
COVPDB714 DSB 1EB3
-
-
SHOW
COVPDB680 DAV 1H7O
-
-
SHOW
COVPDB1308 SHF 1H7N
-
-
SHOW
COVPDB1022 KAH 1H7P
-
-
SHOW