COVPDB

Protein
Protein Name	Beta-lactamase
#PDB ID	20
Organism	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Uniprot ID/ACC	P9WKD3 (BLAC_MYCTU)
Synonym(s)	class A beta-lactamase BlaA MCAN_RS10925 MCAN_20911 show 2 synonym(s)
Gene Symbol	blaC
Gene ID	45426045
Sequence	MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREALLAEAATCVAGVLA
Protein Class	HYDROLASE
Function	Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of M.tuberculosis to beta-lactam antibiotics.