Protein |
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| Protein Name | Decaprenylphosphoryl-beta-D-ribose oxidase | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 6 | |||||
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |||||
| Uniprot ID/ACC | P9WJF1 (DPRE1_MYCTU) | |||||
| Synonym(s) |
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| Gene Symbol | dprE1 | |||||
| Gene ID | 886125 | |||||
| Sequence | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL | |||||
| Protein Class | OXIDOREDUCTASE | |||||
| Function | Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans (PubMed:16291675, PubMed:19299584). DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX) (PubMed:22733761). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex (PubMed:25789990). Can also use farnesyl-phosphoryl-beta-D-ribofuranose (FPR) as substrate in vitro (PubMed:25427196). Appears to be essential for the growth and survival of M.tuberculosis (PubMed:12657046, PubMed:24517327). DprE1 is a highly vulnerable and fully validated tuberculosis drug target. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB119 | 26J | 6HF3 |
- |
- |
 |
SHOW |
| COVPDB822 | G1H | 6HF0 |
- |
- |
 |
SHOW |
| COVPDB119 | 26J | 4NCR |
- |
- |
|
SHOW |
| COVPDB42 | 0SK | 6HEZ |
- |
- |
 |
SHOW |
| COVPDB823 | G1T | 6HFV |
- |
- |
 |
SHOW |
| COVPDB43 | 0T4 | 4FDN |
- |
- |
 |
SHOW |