Protein |
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Protein Name | Thymidylate synthase | |||||
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#PDB ID | 13 | |||||
Organism | Escherichia coli (strain K12) | |||||
Uniprot ID/ACC | P0A884 (TYSY_ECOLI) | |||||
Synonym(s) |
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Gene Symbol | thyA | |||||
Gene ID | 58461970 | |||||
Sequence | MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI | |||||
Protein Class | TRANSFERASE | |||||
Function | Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product (PubMed:3286637, PubMed:2223754, PubMed:9826509). This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation (PubMed:7708505). |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
COVPDB1415 | UFP | 1TSN | Ki : 10 nM | BindingDB | SHOW | |
COVPDB1415 | UFP | 1BJG |
- |
- |
SHOW | |
COVPDB1422 | UMC | 6CDZ |
- |
- |
SHOW | |
COVPDB1422 | UMC | 6NNR |
- |
- |
SHOW | |
COVPDB1141 | NDU | 3BFI |
- |
- |
SHOW | |
COVPDB1422 | UMC | 4GEV |
- |
- |
SHOW | |
COVPDB1141 | NDU | 3BHR |
- |
- |
SHOW | |
COVPDB1393 | TP2 | 1F4C |
- |
- |
SHOW | |
COVPDB1141 | NDU | 3BHL |
- |
- |
SHOW | |
COVPDB1393 | TP2 | 1F4D |
- |
- |
SHOW | |
COVPDB1422 | UMP | 1KZI |
- |
- |
SHOW | |
COVPDB1141 | NDU | 3B9H |
- |
- |
SHOW | |
COVPDB1422 | UMP | 1TRG |
- |
- |
SHOW |