Covpdb











Protein
Protein Name Beta-lactamase
#PDB ID 56
Organism Escherichia coli (strain K12)
Uniprot ID/ACC P00811 (AMPC_ECOLI)
Synonym(s)
  •   b4150
  • ECK4146
  • ampA
show 2 synonym(s)
Gene Symbol ampC
Gene ID 948669
Sequence MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
Protein Class HYDROLASE
Function This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB33 0N3 4E3I Ki : 1.3 nM PDBBind SHOW
COVPDB34 0N4 4E3J Ki : 1.2 nM PDBBind SHOW
COVPDB35 0NA 4E3K Ki : 0.8 nM PDBBind SHOW
COVPDB36 0NB 4E3L Ki : 3 nM PDBBind SHOW
COVPDB37 0ND 4E3M Ki : 0.2 nM PDBBind SHOW
COVPDB38 0NE 4E3N Ki : 0.05 nM PDBBind SHOW
COVPDB39 0NG 4E3O Ki : 310 nM PDBBind SHOW
COVPDB54 105 1FSY Ki : 150 nM PDBBind SHOW
COVPDB54 105 1FSY Ki : 150 nM BindingDB SHOW
COVPDB117 25N 4LV3 Ki : 3200 nM PDBBind SHOW
COVPDB223 4CB 1KDW Ki : 2900 nM PDBBind SHOW
COVPDB223 4CB 1KDW Ki : 2900 nM BindingDB SHOW
COVPDB502 APB 3BLS Ki : 7300 nM PDBBind SHOW
COVPDB502 APB 3BLS Ki : 7300 nM BindingDB SHOW
COVPDB550 BDB 1KE3 Ki : 200 nM PDBBind SHOW
COVPDB550 BDB 1KE3 Ki : 200 nM BindingDB SHOW
COVPDB580 BSF 3O86 Ki : 70 nM PDBBind SHOW
COVPDB581 BSG 3O87 Ki : 25 nM PDBBind SHOW
COVPDB582 BSH 3O88 Ki : 430 nM PDBBind SHOW
COVPDB596 BZB 1C3B Ki : 27 nM PDBBind SHOW
COVPDB596 BZB 3FKV IC50 : 200 nM, Ki : 27 nM, IC50 : 150 nM, IC50 : 300 nM BindingDB SHOW
COVPDB596 BZB 3IXG IC50 : 100-200 nM, Ki : 27 nM BindingDB SHOW
COVPDB621 C9P 3BM6 Ki : 26 nM PDBBind SHOW
COVPDB625 CB4 1IEM Ki : 20 nM PDBBind SHOW
COVPDB657 CTB 1FSW Ki : 320 nM PDBBind SHOW
COVPDB657 CTB 1FSW Ki : 320 nM BindingDB SHOW
COVPDB658 CVB 1KE0 Ki : 4200 nM PDBBind SHOW
COVPDB658 CVB 1KE0 Ki : 4200 nM BindingDB SHOW
COVPDB770 ETP 1GA9 Ki : 83 nM PDBBind SHOW
COVPDB770 ETP 1GA9 Ki : 80 nM BindingDB SHOW
COVPDB1151 NPB 1KDS IC50 : 5000 nM, Ki : 1700 nM BindingDB SHOW
COVPDB1219 PCN 1LLB IC50 : 900 nM PDBBind SHOW
COVPDB1317 SM2 1PI5 Ki : 17 nM PDBBind SHOW
COVPDB1317 SM2 1PI5 Ki : 17 nM Binding MOAD SHOW
COVPDB1317 SM2 1MXO Ki : 1 nM PDBBind SHOW
COVPDB1318 SM3 1PI4 Ki : 37 nM PDBBind SHOW
COVPDB1318 SM3 1PI4 Ki : 37 nM Binding MOAD SHOW
COVPDB1318 SM3 1MY8 Ki : 35 nM PDBBind SHOW
COVPDB1318 SM3 1MY8 Ki : 35 nM Binding MOAD SHOW
COVPDB1319 SM4 2RCX Ki : 1 nM PDBBind SHOW
COVPDB1441 VA1 2I72 Ki : 37 nM PDBBind SHOW
COVPDB596 BZB 3IXB Ki : 27 nM, IC50 : 150-300 nM BindingDB SHOW
COVPDB502 APB 4LV0 Ki : 7300 nM BindingDB SHOW
COVPDB1035 KL8 6YPD
-
-
SHOW
COVPDB1199 OX6 2PU4
-
-
SHOW
COVPDB1073 LOR 1FCN
-
-
SHOW
COVPDB153 2TV 4OLG
-
-
SHOW
COVPDB624 CAZ 1IEL
-
-
SHOW
COVPDB435 9EP 6WHF
-
-
SHOW
COVPDB942 IM2 1LL5
-
-
SHOW
COVPDB1034 KJK 6YEN
-
-
SHOW
COVPDB1200 OX7 2PU4
-
-
SHOW
COVPDB632 CEF 4KG5
-
-
SHOW
COVPDB435 CEO 1KVM
-
-
SHOW
COVPDB1318 SM3 2FFY
-
-
SHOW
COVPDB664 CXU 1FCM
-
-
SHOW
COVPDB85 1S7 4KEN
-
-
SHOW
COVPDB1115 MXG 1O07
-
-
SHOW
COVPDB435 KCP 1KVL
-
-
SHOW
COVPDB632 CEF 3IXH
-
-
SHOW
COVPDB90 1S6 4JXG
-
-
SHOW
COVPDB516 AXL 1LL9
-
-
SHOW
COVPDB632 CEF 4KG2
-
-
SHOW
COVPDB191 MOX 1I5Q
-
-
SHOW
COVPDB191 MOX 1FCO
-
-
SHOW
COVPDB1184 OK3 6YEO
-
-
SHOW