| Protein Name |
N-lysine methyltransferase KMT5A |
| #PDB ID |
3
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
Q9NQR1 (KMT5A_HUMAN)
|
| Synonym(s) |
- H4-K20-HMTase KMT5A
- H4-K20-HMTase SETD8
- H4-K20-specific histone methyltransferase
- H4K20-specific histone methyltransferase splice variant Set8b
- N-lysine methyltransferase SETD8
- PR/SET domain containing protein 8
- PR/SET domain-containing protein 07
- SET domain containing (lysine methyltransferase) 8
- SET domain-containing protein 8
- histone-lysine N-methyltransferase KMT5A
- histone-lysine N-methyltransferase SETD8
- lysine (K)-specific methyltransferase 5A
- lysine N-methyltransferase 5A
- lysine-specific methylase 5A
- PR-Set7
- PR/SET07
- SET07
- SET8
- SETD8
show 18 synonym(s)
|
| Gene Symbol |
KMT5A
|
| Gene ID |
387893
|
| Sequence |
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH |
| Protein Class |
TRANSFERASE |
| Function |
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
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