Protein
Protein Name Proteasome subunit beta type-2
#PDB ID 5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Uniprot ID/ACC P25043 (PSB2_YEAST)
Synonym(s)
  •   proteasome core particle subunit beta 2
  • YOR157C
show 1 synonym(s)
Gene Symbol PUP1
Gene ID 854328
Sequence MAGLSFDNYQRNNFLAENSHTQPKATSTGTTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEEQVDITA
Protein Class HYDROLASE
Function The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB180 38N 4QLQ IC50 : 6.6 nM PDBBind SHOW
COVPDB1444 VOL 4Y70
-
-
SHOW
COVPDB122 2A1 4Y7Y
-
-
SHOW
COVPDB847 GAU 4YA5
-
-
SHOW
COVPDB846 GAU 4Y7W
-
-
SHOW