Protein
Protein Name Urokinase-type plasminogen activator
#PDB ID 4
Organism Homo sapiens (Human)
Uniprot ID/ACC P00749 (UROK_HUMAN)
Synonym(s)
  •   U-plasminogen activator
  • plasminogen activator
  • urinary
  • ATF
  • BDPLT5
  • QPD
  • UPA
  • URK
  • u-PA
show 8 synonym(s)
Gene Symbol PLAU
Gene ID 5328
Sequence MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
Protein Class HYDROLASE
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1306 SH1 1W14 Ki : 3 nM PDBBind SHOW
COVPDB1314 SJ1 1W10 Ki : 28 nM PDBBind SHOW
COVPDB1315 SL1 1W12 Ki : 14 nM PDBBind SHOW
COVPDB388 7YF 5WXS
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SHOW