Protein |
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| Protein Name | Epidermal growth factor receptor | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 15 | |||||
| Organism | Homo sapiens (Human) | |||||
| Uniprot ID/ACC | P00533 (EGFR_HUMAN) | |||||
| Synonym(s) |
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| Gene Symbol | EGFR | |||||
| Gene ID | 1956 | |||||
| Sequence | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA | |||||
| Protein Class | TRANSFERASE | |||||
| Function | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Isoform 2 may act as an antagonist of EGF action. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB76 | 1E8 | 5YU9 | Kd : 180 nM | PDBBind |  |
SHOW |
| COVPDB390 | 80U | 5GNK | IC50 : 5.3 nM | PDBBind |  |
SHOW |
| COVPDB393 | 8AM | 5UG9 | Ki : 8 nM | PDBBind |  |
SHOW |
| COVPDB394 | 8BP | 5UG8 | Ki : 2 nM | PDBBind |  |
SHOW |
| COVPDB395 | 8BS | 5UGC | Ki : 13 nM | PDBBind |  |
SHOW |
| COVPDB910 | HKI | 3W2Q | IC50 : 66 nM | PDBBind |  |
SHOW |
| COVPDB1453 | W2P | 3W2P | IC50 : 8100 nM | PDBBind |  |
SHOW |
| COVPDB75 | 1C9 | 4I24 | IC50 : 0.63 nM, IC50 : 1.8 nM, IC50 : 6.9 nM, IC50 : 6 nM, IC50 : 11 nM, IC50 : 42 nM | BindingDB |  |
SHOW |
| COVPDB1261 | QP1 | 6V66 |
- |
- |
 |
SHOW |
| COVPDB1163 | O44 | 5U8L |
- |
- |
 |
SHOW |
| COVPDB1262 | QQJ | 6V6K |
- |
- |
 |
SHOW |
| COVPDB399 | 8JC | 5XDK |
- |
- |
 |
SHOW |
| COVPDB1263 | QQM | 6V6O |
- |
- |
 |
SHOW |
| COVPDB1493 | YY3 | 6JXT |
- |
- |
 |
SHOW |
| COVPDB705 | DJK | 4LQM |
- |
- |
 |
SHOW |