Protein

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Protein Name Eukaryotic translation initiation factor 4E
#PDB ID 12
Organism Homo sapiens
Uniprot ID/ACC P06730 (IF4E_HUMAN)
Protein Sequence MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Protein Class TRANSLATION REGULATOR
Synonym(s)
  •   eukaryotic translation initiation factor 4E
  • eIF-4F 25 kDa subunit
  • eukaryotic translation initiation factor 4E-like 1
  • mRNA cap-binding protein
  • AUTS19
  • CBP
  • EIF4E1
  • EIF4EL1
  • EIF4F
  • eIF-4E
show 9 synonym(s)
Gene Symbol EIF4E
Gene ID 1977
Pfam ID PF01652
Interpro ID IPR023398, IPR001040, IPR019770
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
MGP Small Molecule 1IPC Kd : 10.0 nM, Kd : 28.0 nM, Kd : 2360.0 nM, Kd : 5720.0 nM BindingDB SHOW
MGQ Small Molecule 2V8X Kd : 790.0 nM, Kd : 1320.0 nM, Kd : 15500.0 nM, Kd : 26800.0 nM BindingDB SHOW
MGQ Small Molecule 2V8X Kd : 6950.0 nM Binding MOAD SHOW
MGP Small Molecule 3AM7 Kd : 10.0 nM, Kd : 28.0 nM, Kd : 2360.0 nM, IC50 : 5720.0 nM BindingDB SHOW
MGV Small Molecule 2V8Y Kd : 7510.0 nM, Kd : 8220.0 nM BindingDB SHOW
MGV Small Molecule 2V8Y Kd : 1960.0 nM Binding MOAD SHOW
MGP Small Molecule 5T46 Kd : 10.0 nM, Kd : 28.0 nM, Kd : 5720.0 nM, Kd : 2360.0 nM BindingDB SHOW
MGO Small Molecule 2W97 Kd : 9.0 nM Binding MOAD SHOW
MGP Small Molecule 4TPW Ki : 28.0 nM, IC50 : 2360.0 nM, Kd : 10.0 nM, IC50 : 5720.0 nM BindingDB SHOW
M7G Small Molecule 4TQC
-
-
SHOW
MGO Small Molecule 4AZA
-
-
SHOW
6G6 Small Molecule 5J5Y
-
-
SHOW
GTA Small Molecule 1IPB
-
-
SHOW
MGT Small Molecule 5ZK7
-
-
SHOW