Ligand Download |
||
Ligand Name: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE | ||
HET ID: MGP | PubChem: 135419182 | |
DrugBank: DB02716 | ChEMBL: CHEMBL1234303 | |
Canonical SMILES: O[C@@H]1[C@@H](CO[P@](=O)(O[P@](=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1c[n+](c2c1nc(N)[nH]c2=O)C | ||
Standard InChI: InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p+1/t4-,6-,7-,10-/m1/s1 | ||
Molecular Formula: C11H19N5O14P3+ | Mol. Weight: 538.21497 | Heavy Atoms: 33 |
Charge: 1 | Is Chiral: True | logP: -2.325 |
HBD: 8 | HBA: 17 | TPSA: 319.52 |
#Bonds: 40 | #Rotatable Bonds: 8 | Shape Complexity: 0.54545456 |
Stereocomplexity: 0.54545456 |
Bound Proteins |
Protein Name | Uniprot ID/ACC | Organism | PDB ID | Binding Affinity | Binding Database | Complex Card |
Eukaryotic translation initiation factor 4E | P63073 (IF4E_MOUSE) | Mus musculus | 1L8B | Kd : 10.0 nM, Kd : 28.0 nM, Kd : 5720.0 nM, Kd : 2360.0 nM | BindingDB | SHOW |
Eukaryotic translation initiation factor 4E | P63073 (IF4E_MOUSE) | Mus musculus | 1L8B | Kd : 140.0 nM | Binding MOAD | SHOW |
Eukaryotic translation initiation factor 4E | P06730 (IF4E_HUMAN) | Homo sapiens | 1IPC | Kd : 10.0 nM, Kd : 28.0 nM, Kd : 2360.0 nM, Kd : 5720.0 nM | BindingDB | SHOW |
Eukaryotic translation initiation factor 4E | P63073 (IF4E_MOUSE) | Mus musculus | 5BXV | Kd : 10.0 nM, Kd : 28.0 nM, Kd : 5720.0 nM, Kd : 2360.0 nM | BindingDB | SHOW |
Eukaryotic translation initiation factor 4E | P06730 (IF4E_HUMAN) | Homo sapiens | 3AM7 | Kd : 10.0 nM, Kd : 28.0 nM, Kd : 2360.0 nM, IC50 : 5720.0 nM | BindingDB | SHOW |
Eukaryotic translation initiation factor 4E | P06730 (IF4E_HUMAN) | Homo sapiens | 5T46 | Kd : 10.0 nM, Kd : 28.0 nM, Kd : 5720.0 nM, Kd : 2360.0 nM | BindingDB | SHOW |
Putative Eukaryotic translation initiation factor 4E type 5 | A0A2V2VRR6 (A0A2V2VRR6_TRYCR) | Trypanosoma cruzi | 6O80 | Kd : 21000.0 nM | Binding MOAD | SHOW |
Eukaryotic translation initiation factor 4E | P06730 (IF4E_HUMAN) | Homo sapiens | 4TPW | Ki : 28.0 nM, IC50 : 2360.0 nM, Kd : 10.0 nM, IC50 : 5720.0 nM | BindingDB | SHOW |
Replicase | F1BV96 (F1BV96_9VIRU) | SFTS virus AH12 | 6XYA |
- |
- |
SHOW |
Eukaryotic translation initiation factor 4E1 | P48598 (IF4E_DROME) | Drosophila melanogaster | 5T48 |
- |
- |
SHOW |
Eukaryotic translation initiation factor 4E | P63073 (IF4E_MOUSE) | Mus musculus | 6GKJ |
- |
- |
SHOW |
Eukaryotic translation initiation factor 4E | P07260 (IF4E_YEAST) | Saccharomyces cerevisiae | 6FC1 |
- |
- |
SHOW |
Eukaryotic translation initiation factor 4E-3 | O61955 (IF4E3_CAEEL) | Caenorhabditis elegans | 5ABX |
- |
- |
SHOW |