| Protein Name |
3-dehydroquinate dehydratase |
| #PDB ID |
2
|
| Organism |
Clostridioides difficile (strain 630) (Peptoclostridium difficile) |
| Uniprot ID/ACC |
Q186A6 (AROD_CLOD6)
|
| Synonym(s) |
- type I 3-dehydroquinate dehydratase
- BZ168_RS07185
- BZ168_07190
show 2 synonym(s)
|
| Gene Symbol |
aroD
|
| Gene ID |
57297922
|
| Sequence |
MKRKVQVKNITIGEGRPKICVPIIGKNKKDIIKEAKELKDACLDIIEWRVDFFENVENIKEVKEVLYELRSYIHDIPLLFTFRSVVEGGEKLISRDYYTTLNKEISNTGLVDLIDVELFMGDEVIDEVVNFAHKKEVKVIISNHDFNKTPKKEEIVSRLCRMQELGADLPKIAVMPQNEKDVLVLLEATNEMFKIYADRPIITMSMSGMGVISRLCGEIFGSALTFGAAKSVSAPGQISFKELNSVLNLLHKSIN |
| Protein Class |
LYASE |
| Function |
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of Lys-170 at the active site.
|
