Protein
Protein Name Strigolactone esterase D14
#PDB ID 4
Organism Oryza sativa subsp. japonica (Rice)
Uniprot ID/ACC Q10QA5 (D14_ORYSJ)
Synonym(s)
  •   LOC_Os03g10620
  • Protein DWARF-14
  • Protein DWARF-88
  • Protein HIGH-TILLERING DWARF 2
  • dwarf 88 esterase
  • probable strigolactone esterase D14
  • OSNPB_030203200
  • D14
  • D88
  • HTD2
show 9 synonym(s)
Gene Symbol D14
Gene ID 4331983
Sequence MLRSTHPPPSSPSSSSSGGGGGGGSSASSSSEKTMVGGGGGGGGGSGSAAPSGAKLLQILNVRVVGSGERVVVLSHGFGTDQSAWSRVLPYLTRDHRVVLYDLVCAGSVNPDHFDFRRYDNLDAYVDDLLAILDALRIPRCAFVGHSVSAMIGILASIRRPDLFAKLVLIGASPRFLNDSDYHGGFELEEIQQVFDAMGANYSAWATGYAPLAVGADVPAAVQEFSRTLFNMRPDISLHVCQTVFKTDLRGVLGMVRAPCVVVQTTRDVSVPASVAAYLKAHLGGRTTVEFLQTEGHLPHLSAPSLLAQVLRRALARY
Protein Class HYDROLASE
Function Involved in strigolactone (SL) signaling pathway. May function downstream of SL synthesis, as a component of hormone signaling or as an enzyme that participates in the conversion of SL to the bioactive form. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds (PubMed:19579033, PubMed:19542179, PubMed:23301669). Strigolactone-dependent association of D14 with D3 and D53 (a repressor of SL signaling) triggers D53 ubiquitination and degradation (PubMed:24336200, PubMed:24616269). Hydrolyzes the butenolide ring of SLs (PubMed:23381136, PubMed:24131983). A reaction product D-OH is trapped in the cavity of D14, inducing the interaction with SLR1, and probably with other proteins such as D3 and D53 (PubMed:24131983). Contributes to the negative regulation of gibberellin signaling (PubMed:24131983).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1038 KOK 5ZHR
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-
SHOW
COVPDB438 9GU 5ZHT
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-
SHOW
COVPDB1188 OPL 4IHA
-
-
SHOW
COVPDB1025 KAT 5ZHS
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SHOW