| Protein Name |
GTPase KRas |
| #PDB ID |
43
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P01116 (RASK_HUMAN)
|
| Synonym(s) |
- K-ras p21 protein
- Kirsten rat sarcoma viral oncogene homolog
- Kirsten rat sarcoma viral proto-oncogene
- PR310 c-K-ras oncogene
- c-Kirsten-ras protein
- cellular c-Ki-ras2 proto-oncogene
- cellular transforming proto-oncogene
- oncogene KRAS2
- transforming protein p21
- v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
- C-K-RAS
- CFC2
- K-RAS2A
- K-RAS2B
- K-RAS4A
- K-RAS4B
- K-Ras
- K-Ras 2
- KI-RAS
- KRAS1
- KRAS2
- NS
- NS3
- OES
- RALD
- RASK2
- c-Ki-ras
- c-Ki-ras2
show 27 synonym(s)
|
| Gene Symbol |
KRAS
|
| Gene ID |
3845
|
| Sequence |
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM |
| Protein Class |
SIGNALING PROTEIN |
| Function |
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).
|
