 |
| Ligand Name: AMG 510 |
| Ligand Type: non-polymer |
| Ligand ID: COVPDB1100 |
PubChem:
137278711
|
Synonym(s):
- amg-510
- amg510
- amg-510 racemate
- sotorasib
- 2252403-56-6
- kras g12c inhibitor 9
- 2296729-00-3
- unii-2b2vm6uc8g
- 2b2vm6uc8g
- chembl4535757
- 2296729-00-3 (racemate)
- 4-((s)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1h)-one
- 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2s)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
- sotorasib [inn]
- 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-((2s)-2-methyl-4-prop-2-enoylpiperazin-1-yl)pyrido(2,3-d)pyrimidin-2-one
- amg510 racemate
- sotorasib [usan]
- amg-510(racemate)
- kras mutant-targeting amg 510
- schembl20560375
- gtpl10678
- amg 510 pound>>amg-510
- amy16918
- bcp30452
- bcp33368
- ex-a3538
- bdbm50514402
- nsc818433
- s8830
- who 11370
- db15569
- nsc-818433
- bs-16684
- hy-114277
- cs-0081316
- compound (r)-38 [pmid: 31820981]
- amg510 ; amg 510; amg-510; amg510
- (1m)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-4-((2s)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl)pyrido(2,3-d)pyrimidin-2(1h)-one
- (1s)-4-((s)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1h)-one
- 2296729-66-1
- pyrido(2,3-d)pyrimidin-2(1h)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(1-methylethyl)-3-pyridinyl)-4-((2s)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl)-
show 40 synonym(s)
|
| DrugBank: DB15569 |
ChEMBL: CHEMBL4535757 |
| Canonical SMILES: Fc1cccc(O)c1-c(n2)c(F)cc(c23)c(N4CCN(C[C@@H]4C)C(=O)C=C)nc(=O)n3-c5c(C)ccnc5C(C)C |
| Standard InChI: InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1 |
| Molecular Formula: C30H30F2N6O3 |
Mol. Weight: 560.23474 |
logP: 4.48142 |
| HBD: 1 | HBA: 8 |
| #Rotatable Bonds: 5 | TPSA: 104.45 |