Protein

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Protein Name Poly [ADP-ribose] polymerase 1
#PDB ID 3
Organism Homo sapiens
Uniprot ID/ACC P09874 (PARP1_HUMAN)
Protein Sequence MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
Protein Class TRANSCRIPTION REGULATOR
Synonym(s)
  •   poly [ADP-ribose] polymerase 1
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
  • ADP-ribosyltransferase NAD(+)
  • ADP-ribosyltransferase diphtheria toxin-like 1
  • DNA ADP-ribosyltransferase PARP1
  • NAD(+) ADP-ribosyltransferase 1
  • poly (ADP-ribose) polymerase family, member 1
  • poly(ADP-ribose) synthetase
  • poly(ADP-ribosyl)transferase
  • poly[ADP-ribose] synthase 1
  • protein poly-ADP-ribosyltransferase PARP1
  • ADPRT
  • ADPRT 1
  • ADPRT1
  • ARTD1
  • PARP
  • PARP-1
  • PPOL
  • pADPRT-1
show 18 synonym(s)
Gene Symbol PARP1
Gene ID 142
Pfam ID PF00533, PF08063, PF00644, PF02877, PF05406, PF00645
Interpro ID IPR001357, IPR036420, IPR012982, IPR038650, IPR008288, IPR012317, IPR004102, IPR036616, IPR036930, IPR008893, IPR001510, IPR036957
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
15S Small Molecule 4HHZ IC50 : 19.0 nM PDBBind SHOW
AAI Small Molecule 2RCW Ki : 8.0 nM, EC50 : 3.0 nM BindingDB SHOW
UHB Small Molecule 6VKQ
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