Protein |
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Protein Name | Cathepsin K | |||||
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#PDB ID | 38 | |||||
Organism | Homo sapiens (Human) | |||||
Uniprot ID/ACC | P43235 (CATK_HUMAN) | |||||
Synonym(s) |
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Gene Symbol | CTSK | |||||
Gene ID | 1513 | |||||
Sequence | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM | |||||
Protein Class | HYDROLASE | |||||
Function | Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042). |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
COVPDB11 | 0D6 | 1MEM | Ki : 11.5 nM | PDBBind | SHOW | |
COVPDB30 | 0LC | 4DMY | IC50 : <1 nM | PDBBind | SHOW | |
COVPDB128 | 2CA | 1NLJ | IC50 : 70-80 nM, IC50 : 70 nM, IC50 : 80 nM, Ki : 60 nM, Ki : 0.16 nM | BindingDB | SHOW | |
COVPDB184 | 3FC | 1YT7 | IC50 : 130 nM, IC50 : 0.13 nM | BindingDB | SHOW | |
COVPDB209 | 3Y2 | 4X6J | Ki : 16 nM | PDBBind | SHOW | |
COVPDB241 | 4PR | 2BDL | IC50 : 15 nM | PDBBind | SHOW | |
COVPDB350 | 7AS | 5TDI | Ki : 0.18 nM | PDBBind | SHOW | |
COVPDB645 | CKE | 2R6N | IC50 : 1 nM | PDBBind | SHOW | |
COVPDB654 | CT1 | 2AUX | IC50 : 0.5 nM | PDBBind | SHOW | |
COVPDB654 | CT1 | 2AUX | IC50 : 0.5 nM | BindingDB | SHOW | |
COVPDB655 | CT2 | 2AUZ | IC50 : 0.35 nM | PDBBind | SHOW | |
COVPDB655 | CT2 | 2AUZ | IC50 : 0.35 nM | BindingDB | SHOW | |
COVPDB815 | FSP | 1TU6 | IC50 : 0.83 nM | PDBBind | SHOW | |
COVPDB815 | FSP | 1TU6 | IC50 : 0.83 nM | BindingDB | SHOW | |
COVPDB929 | I10 | 1BGO | Ki : 3.5 nM | PDBBind | SHOW | |
COVPDB945 | IHE | 1U9V | IC50 : 6 nM | PDBBind | SHOW | |
COVPDB945 | IHE | 1U9V | IC50 : 6 nM | BindingDB | SHOW | |
COVPDB946 | IHI | 1U9W | IC50 : 3.5 nM | PDBBind | SHOW | |
COVPDB946 | IHI | 1U9W | IC50 : 3.5 nM | BindingDB | SHOW | |
COVPDB947 | IHJ | 1U9X | IC50 : 7 nM | PDBBind | SHOW | |
COVPDB947 | IHJ | 1U9X | IC50 : 7 nM | BindingDB | SHOW | |
COVPDB952 | IN6 | 1AYV | Ki : 10 nM | PDBBind | SHOW | |
COVPDB953 | INA | 1AYU | Ki : 0.7 nM | PDBBind | SHOW | |
COVPDB1042 | KWZ | 3KWZ | IC50 : 4 nM | PDBBind | SHOW | |
COVPDB1042 | KWZ | 3KWZ | IC50 : 4 nM | BindingDB | SHOW | |
COVPDB1121 | MYE | 1SNK | IC50 : 0.25 nM | PDBBind | SHOW | |
COVPDB1121 | MYE | 1SNK | IC50 : 0.25 nM | BindingDB | SHOW | |
COVPDB1138 | NBL | 1YK7 | IC50 : 19 nM | PDBBind | SHOW | |
COVPDB1143 | NFT | 1VSN | IC50 : 0.2 nM | PDBBind | SHOW | |
COVPDB1164 | O47 | 3O0U | IC50 : 12 nM | PDBBind | SHOW | |
COVPDB1169 | O75 | 3O1G | IC50 : <1 nM, IC50 : 1 nM | PDBBind | SHOW | |
COVPDB1169 | O75 | 3O1G | IC50 : <1 nM | BindingDB | SHOW | |
COVPDB1171 | O96 | 3OVZ | IC50 : 8.7 nM | PDBBind | SHOW | |
COVPDB1171 | O96 | 3OVZ | IC50 : 8.7 nM | BindingDB | SHOW | |
COVPDB1193 | ORG | 3KW9 | IC50 : 1 nM | PDBBind | SHOW | |
COVPDB1193 | ORG | 3KW9 | IC50 : 1 nM | BindingDB | SHOW | |
COVPDB1194 | ORH | 3KWB | IC50 : 17 nM | PDBBind | SHOW | |
COVPDB1194 | ORH | 3KWB | IC50 : 17 nM | BindingDB | SHOW | |
COVPDB1381 | TCO | 1Q6K | IC50 : 26 nM | PDBBind | SHOW | |
COVPDB1381 | TCO | 1Q6K | IC50 : 26 nM | BindingDB | SHOW | |
COVPDB1381 | TCO | 1Q6K | IC50 : 26 nM | Binding MOAD | SHOW | |
COVPDB29 | 0LB | 4DMX | IC50 : 15 nM, IC50 : 15.8 nM, IC50 : 15.85 nM | BindingDB | SHOW | |
COVPDB208 | 3XT | 4X6H | Ki : 22 nM | Binding MOAD | SHOW | |
COVPDB208 | 3XT | 4X6H | Ki : 22 nM | BindingDB | SHOW | |
COVPDB739 | E64 | 1ATK |
- |
- |
SHOW | |
COVPDB980 | J5T | 6QLW |
- |
- |
SHOW | |
COVPDB951 | IN3 | 1AYW |
- |
- |
SHOW | |
COVPDB903 | HFH | 6QLM |
- |
- |
SHOW | |
COVPDB956 | INP | 1AU4 |
- |
- |
SHOW | |
COVPDB1218 | PCM | 1AU3 |
- |
- |
SHOW | |
COVPDB909 | HKH | 6QLX |
- |
- |
SHOW | |
COVPDB828 | G4B | 6HGY |
- |
- |
SHOW | |
COVPDB977 | J5N | 6QL8 |
- |
- |
SHOW |