| Protein Name |
SUMO-activating enzyme subunit 2 |
| #PDB ID |
1
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
Q9UBT2 (SAE2_HUMAN)
|
| Synonym(s) |
- SUMO-1 activating enzyme subunit 2
- SUMO1 activating enzyme subunit 2
- UBA2
- ubiquitin-activating enzyme E1 homolog
- anthracycline-associated resistance ARX
- ubiquitin-like 1-activating enzyme E1B
- ARX
- HRIHFB2115
- SAE2
show 8 synonym(s)
|
| Gene Symbol |
UBA2
|
| Gene ID |
10054
|
| Sequence |
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD |
| Protein Class |
TRANSFERASE |
| Function |
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
|
