Covpdb











Protein
Protein Name RNA demethylase ALKBH5
#PDB ID 1
Organism Homo sapiens (Human)
Uniprot ID/ACC Q6P6C2 (ALKB5_HUMAN)
Synonym(s)
  •   AlkB family member 5
  • RNA demethylase
  • alkB
  • alkylation repair homolog 5
  • alkylated DNA repair protein alkB homolog 5
  • alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
  • oxoglutarate and iron-dependent oxygenase domain containing
  • probable alpha-ketoglutarate-dependent dioxygenase ABH5
  • ABH5
  • OFOXD
  • OFOXD1
show 10 synonym(s)
Gene Symbol ALKBH5
Gene ID 54890
Sequence MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGAKRKYQEDSDPERSDYEEQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSSVLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH
Protein Class OXIDOREDUCTASE
Function Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N6-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1423 UN9 4NJ4
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