Protein
Protein Name Geranylgeranyl transferase type-2 subunit alpha
#PDB ID 1
Organism Rattus norvegicus (Rat)
Uniprot ID/ACC Q08602 (PGTA_RAT)
Synonym(s)
  •   Rab geranylgeranyl transferase
  • a subunit
  • Rab geranylgeranyltransferase alpha
  • Rab geranylgeranyltransferase
  • alpha subunit
  • geranylgeranyl transferase type II subunit alpha
  • rab GG transferase alpha
  • rab GGTase alpha
  • rab geranyl-geranyltransferase subunit alpha
show 8 synonym(s)
Gene Symbol Rabggta
Gene ID 58983
Sequence MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT
Protein Class TRANSFERASE
Function Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1227 PJA 4EHM IC50 : 1400 nM PDBBind SHOW