Protein
Protein Name Calpain-1 catalytic subunit
#PDB ID 7
Organism Rattus norvegicus (Rat)
Uniprot ID/ACC P97571 (CAN1_RAT)
Synonym(s)
  •   CANP 1
  • calcium-activated neutral proteinase 1
  • calpain 1
  • (mu/I) large subunit
  • calpain mu-type
  • calpain-1 large subunit
  • micromolar-calpain
  • muCANP
show 7 synonym(s)
Gene Symbol Capn1
Gene ID 29153
Sequence MAEELITPVYCTGVSAQVQKQRDKELGLGRHENAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDSRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKILDTDLDGVVTFDLFKWLQLTMFA
Protein Class HYDROLASE
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-364', 'Gly-377' and 'His-399'.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB739 E64 1TLO IC50 : 100000 nM PDBBind SHOW
COVPDB1152 NQG 2NQG IC50 : 333 nM PDBBind SHOW
COVPDB1153 NQI 2NQI IC50 : 784 nM PDBBind SHOW
COVPDB677 D7G 2G8J IC50 : 170 nM BindingDB SHOW
COVPDB1007 K2Z 2R9F
-
-
SHOW
COVPDB876 GRD 2R9C
-
-
SHOW
COVPDB31 0M6 2G8E
-
-
SHOW