Covpdb











Protein
Protein Name Beta-lactamase TEM
#PDB ID 15
Organism Escherichia coli
Uniprot ID/ACC P62593 (BLAT_ECOLX)
Synonym(s)
  •   class A broad-spectrum beta-lactamase TEM-1
  • AJR21_RS21765
  • AJR21_022090
show 2 synonym(s)
Gene Symbol bla
Gene ID 58463483
Sequence MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
Protein Class HYDROLASE
Function TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB54 105 1NYY Ki : 21000 nM PDBBind SHOW
COVPDB565 BJH 1ERQ Ki : 13 nM PDBBind SHOW
COVPDB569 BJP 1ERO Ki : 5.9 nM PDBBind SHOW
COVPDB663 CXB 1NYM Ki : 4000 nM PDBBind SHOW
COVPDB1137 NBF 1NY0 Ki : 1400 nM PDBBind SHOW
COVPDB1317 SM2 1NXY Ki : 64 nM PDBBind SHOW
COVPDB942 IM2 1BT5
-
-
SHOW
COVPDB807 FOS 1AXB
-
-
SHOW
COVPDB566 BJI 1ERM
-
-
SHOW
COVPDB497 ALP 1TEM
-
-
SHOW
COVPDB1232 PNM 1FQG
-
-
SHOW
COVPDB54 105 1JWZ
-
-
SHOW
COVPDB942 IM2 1JVJ
-
-
SHOW
COVPDB625 CB4 1M40
-
-
SHOW
COVPDB625 CB4 1JWV
-
-
SHOW