Covpdb











Protein
Protein Name Methionine aminopeptidase 2
#PDB ID 6
Organism Homo sapiens (Human)
Uniprot ID/ACC P50579 (MAP2_HUMAN)
Synonym(s)
  •   eIF-2-associated p67 homolog
  • initiation factor 2-associated 67 kDa glycoprotein
  • peptidase M 2
  • testicular tissue protein Li 17
  • MAP2
  • MNPEP
  • p67eIF2
show 6 synonym(s)
Gene Symbol METAP2
Gene ID 10988
Sequence MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
Protein Class HYDROLASE
Function Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB246 52T 5CLS IC50 : 220 nM PDBBind SHOW
COVPDB249 57R 5D6F IC50 : 43000 nM PDBBind SHOW
COVPDB425 94A 5D6E IC50 : >50000 nM PDBBind SHOW
COVPDB1389 TN4 1B6A
-
-
SHOW
COVPDB819 FUG 1BOA
-
-
SHOW
COVPDB1197 OVA 1B59
-
-
SHOW