Covpdb











Protein
Protein Name Cathepsin K
#PDB ID 38
Organism Homo sapiens (Human)
Uniprot ID/ACC P43235 (CATK_HUMAN)
Synonym(s)
  •   cathepsin O
  • cathepsin O1
  • cathepsin O2
  • cathepsin X
  • CTS02
  • CTSO
  • CTSO1
  • CTSO2
  • PKND
  • PYCD
show 9 synonym(s)
Gene Symbol CTSK
Gene ID 1513
Sequence MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Protein Class HYDROLASE
Function Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB11 0D6 1MEM Ki : 11.5 nM PDBBind SHOW
COVPDB30 0LC 4DMY IC50 : <1 nM PDBBind SHOW
COVPDB128 2CA 1NLJ IC50 : 70-80 nM, IC50 : 70 nM, IC50 : 80 nM, Ki : 60 nM, Ki : 0.16 nM BindingDB SHOW
COVPDB184 3FC 1YT7 IC50 : 130 nM, IC50 : 0.13 nM BindingDB SHOW
COVPDB209 3Y2 4X6J Ki : 16 nM PDBBind SHOW
COVPDB241 4PR 2BDL IC50 : 15 nM PDBBind SHOW
COVPDB350 7AS 5TDI Ki : 0.18 nM PDBBind SHOW
COVPDB645 CKE 2R6N IC50 : 1 nM PDBBind SHOW
COVPDB654 CT1 2AUX IC50 : 0.5 nM PDBBind SHOW
COVPDB654 CT1 2AUX IC50 : 0.5 nM BindingDB SHOW
COVPDB655 CT2 2AUZ IC50 : 0.35 nM PDBBind SHOW
COVPDB655 CT2 2AUZ IC50 : 0.35 nM BindingDB SHOW
COVPDB815 FSP 1TU6 IC50 : 0.83 nM PDBBind SHOW
COVPDB815 FSP 1TU6 IC50 : 0.83 nM BindingDB SHOW
COVPDB929 I10 1BGO Ki : 3.5 nM PDBBind SHOW
COVPDB945 IHE 1U9V IC50 : 6 nM PDBBind SHOW
COVPDB945 IHE 1U9V IC50 : 6 nM BindingDB SHOW
COVPDB946 IHI 1U9W IC50 : 3.5 nM PDBBind SHOW
COVPDB946 IHI 1U9W IC50 : 3.5 nM BindingDB SHOW
COVPDB947 IHJ 1U9X IC50 : 7 nM PDBBind SHOW
COVPDB947 IHJ 1U9X IC50 : 7 nM BindingDB SHOW
COVPDB952 IN6 1AYV Ki : 10 nM PDBBind SHOW
COVPDB953 INA 1AYU Ki : 0.7 nM PDBBind SHOW
COVPDB1042 KWZ 3KWZ IC50 : 4 nM PDBBind SHOW
COVPDB1042 KWZ 3KWZ IC50 : 4 nM BindingDB SHOW
COVPDB1121 MYE 1SNK IC50 : 0.25 nM PDBBind SHOW
COVPDB1121 MYE 1SNK IC50 : 0.25 nM BindingDB SHOW
COVPDB1138 NBL 1YK7 IC50 : 19 nM PDBBind SHOW
COVPDB1143 NFT 1VSN IC50 : 0.2 nM PDBBind SHOW
COVPDB1164 O47 3O0U IC50 : 12 nM PDBBind SHOW
COVPDB1169 O75 3O1G IC50 : <1 nM, IC50 : 1 nM PDBBind SHOW
COVPDB1169 O75 3O1G IC50 : <1 nM BindingDB SHOW
COVPDB1171 O96 3OVZ IC50 : 8.7 nM PDBBind SHOW
COVPDB1171 O96 3OVZ IC50 : 8.7 nM BindingDB SHOW
COVPDB1193 ORG 3KW9 IC50 : 1 nM PDBBind SHOW
COVPDB1193 ORG 3KW9 IC50 : 1 nM BindingDB SHOW
COVPDB1194 ORH 3KWB IC50 : 17 nM PDBBind SHOW
COVPDB1194 ORH 3KWB IC50 : 17 nM BindingDB SHOW
COVPDB1381 TCO 1Q6K IC50 : 26 nM PDBBind SHOW
COVPDB1381 TCO 1Q6K IC50 : 26 nM BindingDB SHOW
COVPDB1381 TCO 1Q6K IC50 : 26 nM Binding MOAD SHOW
COVPDB29 0LB 4DMX IC50 : 15 nM, IC50 : 15.8 nM, IC50 : 15.85 nM BindingDB SHOW
COVPDB208 3XT 4X6H Ki : 22 nM Binding MOAD SHOW
COVPDB208 3XT 4X6H Ki : 22 nM BindingDB SHOW
COVPDB739 E64 1ATK
-
-
SHOW
COVPDB980 J5T 6QLW
-
-
SHOW
COVPDB951 IN3 1AYW
-
-
SHOW
COVPDB903 HFH 6QLM
-
-
SHOW
COVPDB956 INP 1AU4
-
-
SHOW
COVPDB1218 PCM 1AU3
-
-
SHOW
COVPDB909 HKH 6QLX
-
-
SHOW
COVPDB828 G4B 6HGY
-
-
SHOW
COVPDB977 J5N 6QL8
-
-
SHOW