COVPDB

Protein
Protein Name	Caspase-3
#PDB ID	19
Organism	Homo sapiens (Human)
Uniprot ID/ACC	P42574 (CASP3_HUMAN)
Synonym(s)	CASP-3 CPP-32 PARP cleavage protease SREBP cleavage activity 1 apopain caspase 3 apoptosis-related cysteine peptidase apoptosis-related cysteine protease cysteine protease CPP32 procaspase3 protein Yama CPP32 CPP32B SCA-1 show 13 synonym(s)
Gene Symbol	CASP3
Gene ID	836
Sequence	MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Protein Class	HYDROLASE
Function	Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond (PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800).