| Protein Name |
Aldehyde dehydrogenase, dimeric NADP-preferring |
| #PDB ID |
2
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P30838 (AL3A1_HUMAN)
|
| Synonym(s) |
- dimeric NADP-preferring
- aldehyde dehydrogenase isozyme 3
- aldehyde dehydrogenase type III
- stomach aldehyde dehydrogenase
- ALDH3
- ALDHIII
show 5 synonym(s)
|
| Gene Symbol |
ALDH3A1
|
| Gene ID |
218
|
| Sequence |
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH |
| Protein Class |
OXIDOREDUCTASE |
| Function |
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
|
