Protein
Protein Name Prolyl endopeptidase
#PDB ID 9
Organism Sus scrofa (Pig)
Uniprot ID/ACC P23687 (PPCE_PIG)
Synonym(s)
  •   PE
  • post-proline cleaving enzyme
show 1 synonym(s)
Gene Symbol PREP
Gene ID 445540
Sequence MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNTLQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP
Protein Class HYDROLASE
Function Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB148 2P2 4AMY Ki : 0.015 nM PDBBind SHOW
COVPDB149 2P4 4AMZ Ki : 0.15 nM PDBBind SHOW
COVPDB150 2P6 4AN0 Ki : 0.02 nM, Ki : 0.92 nM, Ki : 0.95 nM, Ki : 0.1 nM, IC50 : 6 nM, IC50 : 0.2 nM, IC50 : 0.22 nM BindingDB SHOW
COVPDB151 2P8 4AN1 Ki : 0.055 nM PDBBind SHOW
COVPDB228 4I4 4BCB IC50 : 3 nM PDBBind SHOW
COVPDB990 JKT 4BCC IC50 : 9 nM PDBBind SHOW
COVPDB1500 ZPR 1QFS IC50 : 0.33-54 nM, Ki : 0.21-4.3 nM, Ki : 4.3 nM, Ki : 0.35 nM, IC50 : 54 nM, IC50 : 1.1 nM, Ki : 0.21 nM, IC50 : 0.33 nM BindingDB SHOW
COVPDB1500 ZPR 1H2Y IC50 : 0.33-54 nM, Ki : 0.21-4.3 nM, Ki : 0.35 nM, Ki : 4.3 nM, IC50 : 0.33 nM, IC50 : 1.1 nM, Ki : 0.21 nM, IC50 : 54 nM BindingDB SHOW
COVPDB1305 SGL 1QFM
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SHOW