Protein |
||||||
Protein Name | Prolyl endopeptidase | |||||
---|---|---|---|---|---|---|
#PDB ID | 9 | |||||
Organism | Sus scrofa (Pig) | |||||
Uniprot ID/ACC | P23687 (PPCE_PIG) | |||||
Synonym(s) |
|
|||||
Gene Symbol | PREP | |||||
Gene ID | 445540 | |||||
Sequence | MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNTLQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP | |||||
Protein Class | HYDROLASE | |||||
Function | Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
COVPDB148 | 2P2 | 4AMY | Ki : 0.015 nM | PDBBind | SHOW | |
COVPDB149 | 2P4 | 4AMZ | Ki : 0.15 nM | PDBBind | SHOW | |
COVPDB150 | 2P6 | 4AN0 | Ki : 0.02 nM, Ki : 0.92 nM, Ki : 0.95 nM, Ki : 0.1 nM, IC50 : 6 nM, IC50 : 0.2 nM, IC50 : 0.22 nM | BindingDB | SHOW | |
COVPDB151 | 2P8 | 4AN1 | Ki : 0.055 nM | PDBBind | SHOW | |
COVPDB228 | 4I4 | 4BCB | IC50 : 3 nM | PDBBind | SHOW | |
COVPDB990 | JKT | 4BCC | IC50 : 9 nM | PDBBind | SHOW | |
COVPDB1500 | ZPR | 1QFS | IC50 : 0.33-54 nM, Ki : 0.21-4.3 nM, Ki : 4.3 nM, Ki : 0.35 nM, IC50 : 54 nM, IC50 : 1.1 nM, Ki : 0.21 nM, IC50 : 0.33 nM | BindingDB | SHOW | |
COVPDB1500 | ZPR | 1H2Y | IC50 : 0.33-54 nM, Ki : 0.21-4.3 nM, Ki : 0.35 nM, Ki : 4.3 nM, IC50 : 0.33 nM, IC50 : 1.1 nM, Ki : 0.21 nM, IC50 : 54 nM | BindingDB | SHOW | |
COVPDB1305 | SGL | 1QFM |
- |
- |
SHOW |