| Protein Name |
Macrophage migration inhibitory factor |
| #PDB ID |
7
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P14174 (MIF_HUMAN)
|
| Synonym(s) |
- L-dopachrome isomerase
- L-dopachrome tautomerase
- epididymis secretory sperm binding protein
- macrophage migration inhibitory factor (glycosylation-inhibiting factor)
- phenylpyruvate tautomerase
- GIF
- GLIF
- MMIF
show 7 synonym(s)
|
| Gene Symbol |
MIF
|
| Gene ID |
4282
|
| Sequence |
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA |
| Protein Class |
ISOMERASE |
| Function |
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
|
