| Protein Name |
Cathepsin B |
| #PDB ID |
3
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P07858 (CATB_HUMAN)
|
| Synonym(s) |
- APP secretase
- amyloid precursor protein secretase
- cathepsin B1
- cysteine protease
- epididymis secretory sperm binding protein
- APPS
- CPSB
- RECEUP
show 7 synonym(s)
|
| Gene Symbol |
CTSB
|
| Gene ID |
1508
|
| Sequence |
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI |
| Protein Class |
HYDROLASE |
| Function |
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105).
|
