Covpdb











Protein
Protein Name Dual specificity mitogen-activated protein kinase kinase 7
#PDB ID 8
Organism Homo sapiens (Human)
Uniprot ID/ACC O14733 (MP2K7_HUMAN)
Synonym(s)
  •   JNK-activating kinase 2
  • MAP kinase kinase 7
  • MAPK/ERK kinase 7
  • SAPK kinase 4
  • c-Jun N-terminal kinase kinase 2
  • stress-activated protein kinase kinase 4
  • JNKK2
  • MAPKK7
  • MEK
  • MEK 7
  • MKK7
  • PRKMK7
  • SAPKK-4
  • SAPKK4
show 13 synonym(s)
Gene Symbol MAP2K7
Gene ID 5609
Sequence MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
Protein Class TRANSFERASE
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB76 8E8 6YG2
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SHOW
COVPDB428 95U 5Z1D
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SHOW
COVPDB314 6HF 6YG3
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SHOW
COVPDB1189 OQ2 6YG7
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SHOW
COVPDB964 J0E 6QG4
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SHOW
COVPDB1190 OQ8 6YG6
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SHOW
COVPDB315 6HL 6QG7
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SHOW
COVPDB392 862 6IB2
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SHOW