Protein |
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| Protein Name | Methionine aminopeptidase | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 1 | |||||
| Organism | Escherichia coli | |||||
| Uniprot ID/ACC | C3TPN7 (C3TPN7_ECOLX) | |||||
| Synonym(s) |
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| Gene Symbol | map_2 | |||||
| Gene ID | 58463819 | |||||
| Sequence | MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE | |||||
| Protein Class | HYDROLASE | |||||
| Function | Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB379 | 7NP | 4PNC | IC50 : 3700 nM | PDBBind |  |
SHOW |