| Protein Name |
3-dehydroquinate dehydratase |
| #PDB ID |
1
|
| Organism |
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
| Uniprot ID/ACC |
P58687 (AROD_SALTY)
|
| Synonym(s) |
|
| Gene Symbol |
aroD
|
| Gene ID |
1252876
|
| Sequence |
MKTVTVRDLVVGEGAPKIIVSLMGKTITDVKSEALAYREADFDILEWRVDHFANVTTAESVLEAAGAIREIITDKPLLFTFRSAKEGGEQALTTGQYIDLNRAAVDSGLVDMIDLELFTGDDEVKATVGYAHQHNVAVIMSNHDFHKTPAAEEIVQRLRKMQELGADIPKIAVMPQTKADVLTLLTATVEMQERYADRPIITMSMSKTGVISRLAGEVFGSAATFGAVKKASAPGQISVADLRTVLTILHQA |
| Protein Class |
LYASE |
| Function |
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site.
|
