Protein |
||||||
| Protein Name | 3-dehydroquinate dehydratase | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 10 | |||||
| Organism | Salmonella typhi | |||||
| Uniprot ID/ACC | P24670 (AROD_SALTI) | |||||
| Synonym(s) | - | |||||
| Gene Symbol | aroD | |||||
| Gene ID | - | |||||
| Sequence | MKTVTVKNLIIGEGMPKIIVSLMGRDINSVKAEALAYREATFDILEWRVDHFMDIASTQSVLTAARVIRDAMPDIPLLFTFRSAKEGGEQTITTQHYLTLNRAAIDSGLVDMIDLELFTGDADVKATVDYAHAHNVYVVMSNHDFHQTPSAEEMVLRLRKMQALGADIPKIAVMPQSKHDVLTLLTATLEMQQHYADRPVITMSMAKEGVISRLAGEVFGSAATFGAVKQASAPGQIAVNDLRSVLMILHNA | |||||
| Protein Class | LYASE | |||||
| Function | Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of Lys-170 at the active site. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB816 | FSQ | 6SFG |
- |
- |
 |
SHOW |
| COVPDB810 | FQZ | 6SFG |
- |
- |
 |
SHOW |
| COVPDB696 | DHS | 1QFE |
- |
- |
 |
SHOW |
| COVPDB696 | VAU | 4UIO |
- |
- |
|
SHOW |
| COVPDB1054 | L9Z | 6SFE |
- |
- |
 |
SHOW |
| COVPDB816 | FSQ | 6H5C |
- |
- |
|
SHOW |
| COVPDB810 | FQZ | 6H5G |
- |
- |
|
SHOW |
| COVPDB1456 | WPL | 4CLM |
- |
- |
 |
SHOW |
| COVPDB1456 | WPL | 6H5D |
- |
- |
|
SHOW |
| COVPDB817 | FT5 | 6H5J |
- |
- |
 |
SHOW |