Protein |
||||||
| Protein Name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 6 | |||||
| Organism | Homo sapiens (Human) | |||||
| Uniprot ID/ACC | Q15750 (M3K7_HUMAN) | |||||
| Synonym(s) | - | |||||
| Gene Symbol | - | |||||
| Gene ID | - | |||||
| Sequence | MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVVTAP | |||||
| Protein Class | TRANSFERASE | |||||
| Function | May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB78 | 1FM | 4GS6 | IC50 : 5.6 nM, IC50 : 8 nM, IC50 : 80 nM, IC50 : 1300 nM, IC50 : 8.1 nM, IC50 : 9 nM, IC50 : 11 nM | BindingDB |  |
SHOW |
| COVPDB269 | 5KW | 5E7R | IC50 : 25 nM | PDBBind |  |
SHOW |
| COVPDB269 | 5KW | 5E7R | IC50 : 25 nM | BindingDB | |
SHOW |
| COVPDB312 | 6H3 | 5J7S | IC50 : 50 nM | PDBBind |  |
SHOW |
| COVPDB313 | 6H4 | 5J8I | IC50 : 5.1 nM | PDBBind |  |
SHOW |
| COVPDB318 | 6L4 | 5JK3 | IC50 : 7.3 nM | PDBBind |  |
SHOW |
| COVPDB1373 | T92 | 5JH6 | IC50 : 3.3 nM | PDBBind |  |
SHOW |