N,N-dimethyltryptamine






Names

    • BDBM50026868
    • 2-(1H-indol-3-yl)-N,N-dimethylethanamine (ACD/Name 4.0)
    • N,N-DIMETHYLTRYPTAMINE [MI]
    • 2-(1H-Indol-3-yl)-N,N-dimethylethanamine
    • (2-Indol-3-ylethyl)dimethylamine
    • DIMETHYLTRYPTAMINE (MART.)
    • 3-(2-DIMETHYLAMINOETHYL) INDOLE
    • WUB601BHAA
    • Indole, 3-[2-(dimethylamino)ethyl]-
    • DTXCID4065313
    • N,N-Dimethyltryptamine, >=97% (HPLC)
    • N-(2-(1H-indol-3-yl)ethyl)-N,N-dimethylamine (ACD/Name 4.0)
    • NSC 63795
    • 3-[2- (dimethylamino)ethyl]-Indole
    • N-DIMETHYLTRYPTAMINE
    • DTXSID60110053
    • CHEMBL12420
    • 2-(1H-indol-3-yl)-ethyl-dimethyl-amine
    • D-5500
    • 2-(3-Indolyl)ethyldimethylamine
    • 1H-Indole-3-ethanamine, N,N-dimethyl-
    • N,N-Dimethyltryptamine (1mg/ml in Acetonitrile)
    • GTPL141
    • (N,N)-Dimethyltryptamine
    • N,N-Dimethyl-1H-indole-3-ethylamine
    • DIMETHYLTRYPTAMINE [WHO-DD]
    • Dimethyltryptamine(DMT)
    • SCHEMBL335710
    • Q407217
    • 1H-INDOLE-3-ETHANAMINE,N,N-DIMETHYL
    • 2-(1H-Indol-3-yl)-N,N-dimethylethanamine #
    • 3-(2-Dimethylaminoethyl)indole
    • EINECS 200-508-4
    • N,N-Dimethyltryptamine, free base
    • DB-308391
    • 3-(2-(dimethylamino)ethyl)-Indole
    • N,N-DIMETHYLTRYPTAMINE
    • N,N-Dimethyltryptamine (1mg/ml in Methanol)
    • NSC63795
    • N,N Dimethyltryptamine
    • STK370594
    • N,N-dimethyl-1H-Indole-3-ethanamine
    • NN-Dimethyltryptamine
    • AS-47089
    • L001288
    • 61-50-7
    • NS00005525
    • UNII-WUB601BHAA
    • 3-[2-(dimethylamino)ethyl]indole
    • [2-(1H-INDOL-3-YL)-ETHYL]-DIMETHYL-AMINE
    • N,N-dimethyl-1H-Indole-3-ethanamine (9CI)
    • C08302
    • 3-(dimethylaminoethyl)-indole
    • Indole, 3-(2-(dimethylamino)ethyl)-
    • NSC-63795
    • METHYL-(2-(1H-INDOL-3-YL)-ETHYL)-METHYLAMINE
    • HSDB 8017
    • (psychogenic)
    • CHEBI:28969
    • 2-(1H-indol-3-yl)-N,N-dimethylethylamine
    • dimethyltryptamine [INN]
    • DEA No. 7435
    • N,N-dimethyltryptamine
    • N,N-Dimethyltryptamine, 1mg/ml in Methanol
    • AKOS005446117
    • InChI=1/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H
    • DIMETHYLTRYPTAMINE [MART.]
    • 2-(1H-INDOL-3-YL)-N,N-DIMETHYL-ETHANAMINE
    • DMT (psychogenic)
    • DIMETHYLTRYPTAMINE
    • BRN 0138259
    • WLN: T56 BMJ D2N1&1
    • [2-(1H-indol-3-yl)ethyl]dimethylamine
    • 3-(2-(DIMETHYLAMINO)ETHYL)INDOLE
    • MB00483
    • DB01488

Attributes

  • Canonical SMILES

    CN(C)CCC1=CNC2=CC=CC=C21

  • InChI

    InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3

  • Molecule Class: Alkaloids
  • TPSA: 19.03
  • #RotBonds: 3
  • MW: 188.274
  • HBD: 1
  • HBA: 1
  • logP: 2.2720000000000002
  • Chemical Formula: C12H16N2


Species

    Species Place of Collection NCBI Taxonomy Voucher Specimen
    T. alba Mexico 761051 132793, 133359, 161424 to 161427
    T. arborea Mexico, Costa Rica 681494 132793, 133359, 161424 to 161427

External Databases


References

  • Quantification of Anti-Addictive Alkaloids Ibogaine and Voacangine in In Vivo- and In Vitro-Grown Plants of Two Mexican Tabernaemontana Species. Chem Biodivers, 2016 (PMID 27448833).

Compound-Protein Relationships


Compound Activities

    • Antiaddictive

Predicted NMR Spectral Data


Predicted MS Fragmentation Patternn


Predicted ADMET Properties

    Category Property Name Predicted Value
    Absorption Caco-2 (logPaap) -4.51
    Human Oral Bioavailability 20% Bioavailable
    Human Intestinal Absorption Absorbed
    Madin-Darby Canine Kidney -4.52
    Human Oral Bioavailability 50% Bioavailable
    P-Glycoprotein Inhibitor Non-Inhibitor
    P-Glycoprotein Substrate Non-Substrate
    Skin Permeability -2.97
    Distribution Blood-Brain Barrier (Central Nervous System) -2.11
    Blood-Brain Barrier Penetrable
    Fraction Unbound (Human) 0.39
    Plasma Protein Binding -0.78
    Steady State Volume of Distribution 4.49
    Metabolism Breast Cancer Resistance Protein Inhibitor
    CYP 1A2 Inhibitor Non-Inhibitor
    CYP 1A2 substrate Substrate
    CYP 2C19 Inhibitor Non-Inhibitor
    CYP 2C19 substrate Substrate
    CYP 2C9 Inhibitor Non-Inhibitor
    CYP 2C9 Substrate Substrate
    CYP 2D6 Inhibitor Non-Inhibitor
    CYP 2D6 Substrate Substrate
    CYP 3A4 Inhibitor Non-Inhibitor
    CYP 3A4 Substrate Non-Substrate
    OATP1B1 Non-Inhibitor
    OATP1B3 Non-Inhibitor
    Excretion Clearance 11.01
    Organic Cation Transporter 2 Inhibitor
    Half-Life of Drug Half-Life < 3hs
    Toxicity AMES Mutagenesis Safe
    Avian Safe
    Bee Safe
    Bioconcentration Factor 1.9
    Biodegradation Safe
    Carcinogenesis Safe
    Crustacean Toxic
    Liver Injury I Safe
    Eye Corrosion Safe
    Eye irritation Safe
    Maximum Tolerated Dose -0.33
    Liver Injury II Toxic
    hERG Blockers Safe
    Daphnia Maga 5.43
    Micronucleos Toxic
    NR-AhR Safe
    NR-AR Safe
    NR-AR-LBD Safe
    NR-Aromatase Safe
    NR-ER Safe
    NR-ER-LBD Safe
    NR-GR Safe
    NR-PPAR-gamma Safe
    NR-TR Safe
    T. Pyriformis 3.09
    Rat (Acute) 2.69
    Rat (Chronic Oral) 2.02
    Fathead Minnow 3.67
    Respiratory Disease Toxic
    Skin Sensitisation Toxic
    SR-ATAD5 Safe
    SR-ARE Safe
    SR-HSE Safe
    SR-MMP Safe
    SR-p53 Safe
    General Properties Boiling Point 291.54
    Hydration Free Energy -10.32
    Log(D) at pH=7.4 0.99
    Log(P) 2.39
    Log S -2.45
    Log(Vapor Pressure) -5.12
    Melting Point 100.28
    pKa Acid 10.72
    pKa Basic 9.86