| Protein Name |
Golgi-associated PDZ and coiled-coil motif-containing protein |
| #PDB ID |
1
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
Q9HD26 (GOPC_HUMAN)
|
| Synonym(s) |
- CFTR-associated ligand
- PDZ protein interacting specifically with TC10
- PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10
- dJ94G16.2 PIST
- fused in glioblastoma
- golgi-associated PDZ and coiled-coil motif containing protein
- CAL
- FIG
- GOPC1
- PIST
- dJ94G16.2
show 10 synonym(s)
|
| Gene Symbol |
GOPC
|
| Gene ID |
57120
|
| Sequence |
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY |
| Protein Class |
TRANSPORTER |
| Function |
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
|
