| Protein Name |
Histone-lysine N-methyltransferase SMYD3 |
| #PDB ID |
2
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
Q9H7B4 (SMYD3_HUMAN)
|
| Synonym(s) |
- SET and MYND domain-containing protein 3
- zinc finger MYND domain-containing protein 1
- zinc finger protein
- subfamily 3A (MYND domain containing)
- 1
- zinc finger
- MYND domain containing 1
- KMT3E
- ZMYND1
- ZNFN3A1
- bA74P14.1
show 10 synonym(s)
|
| Gene Symbol |
SMYD3
|
| Gene ID |
64754
|
| Sequence |
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS |
| Protein Class |
TRANSFERASE |
| Function |
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).
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