| Protein Name |
Methylated-DNA--protein-cysteine methyltransferase |
| #PDB ID |
1
|
| Organism |
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) |
| Uniprot ID/ACC |
Q97VW7 (OGT_SACS2)
|
| Synonym(s) |
- methylated-DNA--[protein]-cysteine S-methyltransferase
- YG5714_RS01395
- YG5714_0282
show 2 synonym(s)
|
| Gene Symbol |
ogt
|
| Gene ID |
7808242
|
| Sequence |
MLVYGLYKSPLGYITVAKDDKGFIMLDFCDCVEGNSRDDSSFTEFFHKLDLYFEGKPINLREPINLKTYPFRLSVFKEVMKIPWGKVMTYKQIADSLGTSPRAVGMALSKNPILLIIPCHRVIAENGIGGYSRGVKLKRALLELEGVKIPE |
| Protein Class |
TRANSFERASE |
| Function |
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
|
