COVPDB

Protein
Protein Name	Isoaspartyl peptidase/L-asparaginase
#PDB ID	1
Organism	Homo sapiens (Human)
Uniprot ID/ACC	Q7L266 (ASGL1_HUMAN)
Synonym(s)	L-asparaginase L-asparagine amidohydrolase asparaginase like 1 asparaginase-like 1 protein asparaginase-like protein 1 beta-aspartyl-peptidase isoaspartyl dipeptidase testis secretory sperm-binding protein Li 242mP ALP ALP1 CRASH show 10 synonym(s)
Gene Symbol	ASRGL1
Gene ID	80150
Sequence	MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP
Protein Class	HYDROLASE
Function	Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.